Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents
UMass Chan Affiliations
Department of Orthopedics and Physical RehabilitationDocument Type
Journal ArticlePublication Date
2019-07-24Keywords
BiomaterialsBiomedical Devices and Instrumentation
Biotechnology
Molecular, Cellular, and Tissue Engineering
Musculoskeletal Diseases
Orthopedics
Metadata
Show full item recordAbstract
Graft-guided regenerative repair of critical long bone defects achieving facile surgical delivery, stable graft fixation, and timely restoration of biomechanical integrity without excessive biotherapeutics remains challenging. Here, we engineered hydration-induced swelling/stiffening and thermal-responsive shape-memory properties into scalable, three-dimensional-printed amphiphilic degradable polymer-osteoconductive mineral composites as macroporous, non-load-bearing, resorbable synthetic grafts. The distinct physical properties of the grafts enabled straightforward surgical insertion into critical-size rat femoral segmental defects. Grafts rapidly recovered their precompressed shape, stiffening and swelling upon warm saline rinse to result in 100% stable graft fixation. The osteoconductive macroporous grafts guided bone formation throughout the defect as early as 4 weeks after implantation; new bone remodeling correlated with rates of scaffold composition-dependent degradation. A single dose of 400-ng recombinant human bone morphogenetic protein-2/7 heterodimer delivered via the graft accelerated bone regeneration bridging throughout the entire defect by 4 weeks after delivery. Full restoration of torsional integrity and complete scaffold resorption were achieved by 12 to 16 weeks after surgery. This biomaterial platform enables personalized bone regeneration with improved surgical handling, in vivo efficacy and safety.Source
Sci Transl Med. 2019 Jul 24;11(502). pii: eaau7411. doi: 10.1126/scitranslmed.aau7411. Link to article on publisher's site
DOI
10.1126/scitranslmed.aau7411Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43009PubMed ID
31341064Related Resources
ae974a485f413a2113503eed53cd6c53
10.1126/scitranslmed.aau7411