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    Multifunctional scaffolds for facile implantation, spontaneous fixation, and accelerated long bone regeneration in rodents

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    Authors
    Zhang, Ben
    Skelly, Jordan D.
    Maalouf, Jacob R.
    Ayers, David C.
    Song, Jie
    UMass Chan Affiliations
    Department of Orthopedics and Physical Rehabilitation
    Document Type
    Journal Article
    Publication Date
    2019-07-24
    Keywords
    Biomaterials
    Biomedical Devices and Instrumentation
    Biotechnology
    Molecular, Cellular, and Tissue Engineering
    Musculoskeletal Diseases
    Orthopedics
    
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    Link to Full Text
    https://doi.org/10.1126/scitranslmed.aau7411
    Abstract
    Graft-guided regenerative repair of critical long bone defects achieving facile surgical delivery, stable graft fixation, and timely restoration of biomechanical integrity without excessive biotherapeutics remains challenging. Here, we engineered hydration-induced swelling/stiffening and thermal-responsive shape-memory properties into scalable, three-dimensional-printed amphiphilic degradable polymer-osteoconductive mineral composites as macroporous, non-load-bearing, resorbable synthetic grafts. The distinct physical properties of the grafts enabled straightforward surgical insertion into critical-size rat femoral segmental defects. Grafts rapidly recovered their precompressed shape, stiffening and swelling upon warm saline rinse to result in 100% stable graft fixation. The osteoconductive macroporous grafts guided bone formation throughout the defect as early as 4 weeks after implantation; new bone remodeling correlated with rates of scaffold composition-dependent degradation. A single dose of 400-ng recombinant human bone morphogenetic protein-2/7 heterodimer delivered via the graft accelerated bone regeneration bridging throughout the entire defect by 4 weeks after delivery. Full restoration of torsional integrity and complete scaffold resorption were achieved by 12 to 16 weeks after surgery. This biomaterial platform enables personalized bone regeneration with improved surgical handling, in vivo efficacy and safety.
    Source

    Sci Transl Med. 2019 Jul 24;11(502). pii: eaau7411. doi: 10.1126/scitranslmed.aau7411. Link to article on publisher's site

    DOI
    10.1126/scitranslmed.aau7411
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43009
    PubMed ID
    31341064
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1126/scitranslmed.aau7411
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    UMass Chan Faculty and Researcher Publications
    Orthopedics and Physical Rehabilitation Publications

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