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    A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites

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    Authors
    Song, Jie
    Saiz, Eduardo
    Bertozzi, Carolyn R.
    UMass Chan Affiliations
    Department of Orthopedics and Physical Rehabilitation
    Document Type
    Journal Article
    Publication Date
    2003-01-30
    Keywords
    Biocompatible Materials
    Bone Substitutes
    Durapatite
    Hydrogels
    Polyhydroxyethyl Methacrylate
    X-Ray Diffraction
    Orthopedics
    Rehabilitation and Therapy
    
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    Link to Full Text
    http://dx.doi.org/10.1021/ja028559h
    Abstract
    As a first step toward the design and fabrication of biomimetic bonelike composite materials, we have developed a template-driven nucleation and mineral growth process for the high-affinity integration of hydroxyapatite with a poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel scaffold. A mineralization technique was developed that exposes carboxylate groups on the surface of cross-linked pHEMA, promoting high-affinity nucleation and growth of calcium phosphate on the surface, along with extensive calcification of the hydrogel interior. Robust surface mineral layers a few microns thick were obtained. The same mineralization technique, when applied to a hydrogel that is less prone to surface hydrolysis, led to distinctly different mineralization patterns, in terms of both the extent of mineralization and the crystallinity of the apatite grown on the hydrogel surface. This template-driven mineralization technique provides an efficient approach toward bonelike composites with high mineral-hydrogel interfacial adhesion strength.
    Source
    J Am Chem Soc. 2003 Feb 5;125(5):1236-43. Link to article on publisher's site
    DOI
    10.1021/ja028559h
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43060
    PubMed ID
    12553825
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1021/ja028559h
    Scopus Count
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    UMass Chan Faculty and Researcher Publications
    Orthopedics and Physical Rehabilitation Publications

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