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dc.contributor.authorStalvey, Michael S.
dc.contributor.authorFlotte, Terence R.
dc.date2022-08-11T08:10:09.000
dc.date.accessioned2022-08-23T16:57:41Z
dc.date.available2022-08-23T16:57:41Z
dc.date.issued2009-10-01
dc.date.submitted2011-10-18
dc.identifier.citationStalvey, M. and Flotte, T. “Endocrine Parameters of Cystic Fibrosis: Back to Basics.” Journal of Cellular Biochemistry 2009 Oct 1;108(2):353-61. DOI: 10.1002/jcb.22284
dc.identifier.issn1097-4644
dc.identifier.doi10.1002/jcb.22284
dc.identifier.pmid19670266
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43201
dc.description.abstractDramatic changes in the life expectancy of cystic fibrosis (CF) patients are occurring, creating a cohort of aging individuals experiencing long-term complications of this chronic disease. The two most common of these complications include CF-related diabetes and CF bone disease. The clinical implications of each have become better understood, as have potential therapies. However, data obtained from the basic science studies of both diseases have not been widely recognized. In this review, we focus on the known and hypothesized pathogenesis of these two disorders. Additionally, the molecular underpinnings of CF will be explained along with the potential interactions with endocrine disease phenotypes.
dc.language.isoen_US
dc.publisherLiss
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19670266&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/jcb.22284
dc.subjectAging
dc.subjectAnimals
dc.subjectBone Diseases, Endocrine
dc.subjectCystic Fibrosis
dc.subjectDiabetes Mellitus
dc.subjectDisease Progression
dc.subjectFemale
dc.subjectHumans
dc.subjectMale
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.subjectPediatrics
dc.titleEndocrine parameters of cystic fibrosis: back to basics
dc.typeJournal Article
dc.source.journaltitleJournal of cellular biochemistry
dc.source.volume108
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_endocrinology/26
dc.identifier.contextkey2301461
html.description.abstract<p>Dramatic changes in the life expectancy of cystic fibrosis (CF) patients are occurring, creating a cohort of aging individuals experiencing long-term complications of this chronic disease. The two most common of these complications include CF-related diabetes and CF bone disease. The clinical implications of each have become better understood, as have potential therapies. However, data obtained from the basic science studies of both diseases have not been widely recognized. In this review, we focus on the known and hypothesized pathogenesis of these two disorders. Additionally, the molecular underpinnings of CF will be explained along with the potential interactions with endocrine disease phenotypes.</p>
dc.identifier.submissionpathpeds_endocrinology/26
dc.contributor.departmentGene Therapy Center
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages353-361


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