Serum Concentrations of Organochlorine Pesticides and Growth among Russian Boys
Authors
Burns, Jane S.Williams, Paige L.
Sergeyev, Oleg
Korrick, Susan A.
Lee, Mary M.
Revich, Boris
Altshul, Larisa
Del Prato, Julie T.
Humblet, Olivier
Patterson, Donald G.
Turner, Wayman E.
Starovoytov, Mikhail
Hauser, Russ
Document Type
Journal ArticlePublication Date
2012-02-01Keywords
Hydrocarbons, ChlorinatedPesticides
Hexachlorobenzene
Growth and Development
Body Mass Index
Russia
Endocrinology, Diabetes, and Metabolism
Pediatrics
Metadata
Show full item recordAbstract
Background: Limited human data suggest an association of organochlorine pesticides (OCPs) with adverse effects on children's growth.Objective: We evaluated the associations of OCPs with longitudinally assessed growth among peripubertal boys from a Russian cohort with high environmental OCP levels. Methods: A cohort of 499 boys enrolled in the Russian Children's Study between 2003 and 2005 at 8-9 years of age were followed prospectively for 4 years. At study entry, 350 boys had serum OCPs measured. Physical examinations were conducted at entry and annually. The longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height, and height velocity were examined by multivariate mixed-effects regression models for repeated measures, controlling for potential confounders. Results: Among the 350 boys with OCP measurements, median serum hexachlorobenzene (HCB), β-hexachlorocyclohexane (βHCH), and p,p´-dichlorodiphenyldichloroethylene (p,p´-DDE) concentrations were 159 ng/g lipid, 168 ng/g lipid, and 287 ng/g lipid, respectively. Age-adjusted BMI and height z-scores generally fell within the normal range per World Health Organization standards at entry and during follow-up. However, in adjusted models, boys with higher serum HCB, βHCH, and p,p´-DDE had significantly lower mean [95% confidence interval (CI)] BMI z-scores, by -0.84 (-1.23, -0.46), -1.32 (-1.70, -0.95), and -1.37 (-1.75, -0.98), respectively, for the highest versus lowest quintile. In addition, the highest quintile of p,p´-DDE was associated with a significantly lower mean (95% CI) height z-score, by -0.69 (-1.00, -0.39) than that of the lowest quintile. Conclusions: Serum OCP concentrations measured at 8-9 years of age were associated with reduced growth, particularly reduced BMI, during the peripubertal period, which may affect attainment of optimal adult body mass and height.Source
Burns JS, Williams PL, Sergeyev O, Korrick SA, Lee MM, Revich B, et al. 2012. Serum Concentrations of Organochlorine Pesticides and Growth among Russian Boys. Environ Health Perspect 120:303-308. http://dx.doi.org/10.1289/ehp.1103743.
DOI
10.1289/ehp.1103743Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43206PubMed ID
21984531Related Resources
Link to article in PubMedRights
EHP is a publication of the U.S. government. Publication of EHP lies in the public domain and is therefore without copyright.ae974a485f413a2113503eed53cd6c53
10.1289/ehp.1103743