The Effects of Vitamin D supplementation on Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Children and Adolescents with Vitamin D Deficiency and Either Type 1 or Type 2 Diabetes Mellitus
Document Type
Journal ArticlePublication Date
2014-06-11Keywords
AdolescentsChildren
Diabetes Mellitus
Fatty Liver
Insulin
Type 2 Diabetes
Vitamin D deficiency
Endocrinology, Diabetes, and Metabolism
Pediatrics
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BACKGROUND: The effects of vitamin D supplementation on mild hepatic dysfunction and glycemic control are unclear in children and adolescents with either type 1 (T1D) or type 2 diabetes (T2D). HYPOTHESIS: Vitamin D supplementation will improve hepatic dysfunction and glycemic control. AIM: To determine the effect of vitamin D supplementation on alanine transaminase (ALT), hemoglobin A1c (HbA1c), and serum 25-hydroxyvitamin D [25(OH)D] concentration. SUBJECTS AND METHODS: A retrospective study of 131 subjects with either T1D (n = 88∶46 females, 42 males), or T2D (n = 43∶26 females, 17 males) of ages 3-18 years between 2007-2013. All subjects had (1) a diagnosis of diabetes for >12 mo, (2) received vitamin D supplementation for the management of vitamin D deficiency (3) had baseline and subsequent simultaneous measurements of HbA1c, ALT, and 25(OH)D. Vitamin D deficiency was defined as 25(OH)D concentration of/L (20 ng/mL). RESULTS: At baseline, vitamin D deficiency occurred in 72.1% of patients with T2D and in 37.5% of T1D patients (p CONCLUSIONS: Vitamin D supplementation in subjects with T2D was associated with statistically significant decreases in BMI SDS, ALT, and a clinically-significant decrease in HbA1c.Source
Nwosu BU, Maranda L (2014) The Effects of Vitamin D Supplementation on Hepatic Dysfunction, Vitamin D Status, and Glycemic Control in Children and Adolescents with Vitamin D Deficiency and Either Type 1 or Type 2 Diabetes Mellitus. PLoS ONE 9(6): e99646. doi:10.1371/journal.pone.0099646. Link to article on publisher's website
DOI
10.1371/journal.pone.0099646Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43222PubMed ID
24918447Notes
Supporting information is available under Additional Files below, and also at http://escholarship.umassmed.edu/datasets/2/.
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Link to article in PubMedRights
Copyright 2014 Nwosu, Maranda. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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10.1371/journal.pone.0099646