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    The effects of aspirin and hypothermia on platelet function in vivo

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    Authors
    Michelson, Alan D.
    Barnard, Marc R.
    Khuri, Shukri F.
    Rohrer, Michael J.
    Macgregor, Hollace
    Valeri, C. Robert
    UMass Chan Affiliations
    Department of Surgery
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    1999-01-01
    Keywords
    Aspirin
    Bleeding Time
    Blood Platelets
    Humans
    *Hyperthermia, Induced
    P-Selectin
    Platelet Aggregation
    Platelet Aggregation Inhibitors
    Thromboxane B2
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1046/j.1365-2141.1999.01146.x
    Abstract
    Patients undergoing hypothermic cardiopulmonary bypass are often receiving aspirin therapy. Hypothermia, aspirin and cardiopulmonary bypass can each induce a platelet function defect, but it is not known if the effects of aspirin and hypothermia are additive in this regard. To address this question in humans in vivo, the forearm skin temperature of healthy volunteers was equilibrated and maintained at either normothermia (32 degrees C) or hypothermia (28 degrees C or 22 degrees C) before and 16 h after the ingestion of 650 mg aspirin. A standardized template bleeding time was performed on the forearm and the shed blood emerging from the wound was assayed for platelet surface P-selectin expression by whole blood flow cytometry (reflecting alpha granule secretion) and thromboxane B2 (the stable metabolite of thromboxane A2) by radioimmunoassay. Hypothermia resulted in marked prolongation of the bleeding time. Aspirin resulted in prolongation of the bleeding time under normothermic conditions, but only minimally augmented the hypothermia-induced prolongation of the bleeding time. Platelet surface P-selectin up-regulation in shed blood was abolished by hypothermia. Aspirin had no effect on maximal platelet surface P-selectin expression under normothermic or hypothermic conditions. Both hypothermia and aspirin resulted in markedly reduced shed blood thromboxane B2. Although aspirin slightly augmented the hypothermia-induced reduction in shed blood thromboxane B2, the concentration of thromboxane generated in shed blood under hypothermic conditions in the absence of aspirin had no effect on platelet surface P-selectin or platelet aggregation in whole blood. In conclusion, as determined by three independent parameters of the shed blood emerging from a standardized bleeding time wound (bleeding time, platelet surface P-selectin, and thromboxane B2), aspirin did not significantly augment hypothermia-induced platelet dysfunction in vivo.
    Source
    Br J Haematol. 1999 Jan;104(1):64-8. DOI: 10.1046/j.1365-2141.1999.01146.x
    DOI
    10.1046/j.1365-2141.1999.01146.x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43336
    PubMed ID
    10027713
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1046/j.1365-2141.1999.01146.x
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