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    Laboratory markers of platelet activation and their clinical significance

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    Authors
    Michelson, Alan D.
    Furman, Mark I.
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    1999-09-01
    Keywords
    Biological Markers
    Cerebrovascular Disorders
    Coronary Disease
    Flow Cytometry
    Humans
    Platelet Activation
    Platelet Aggregation Inhibitors
    Platelet Glycoprotein GPIIb-IIIa Complex
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00062752-199909000-00012&LSLINK=80&D=ovft
    Abstract
    Whole blood flow cytometry is a powerful new laboratory technique for assessment of platelet activation and function. Flow cytometry can be used to measure platelet hyperreactivity, circulating activated platelets, leukocyte-platelet aggregates, and procoagulant platelet-derived microparticles in a number of clinical settings, including acute coronary syndromes, angioplasty, cardiopulmonary bypass, acute cerebrovascular ischemia, peripheral vascular disease, diabetes mellitus, preeclampsia, and Alzheimer's disease. Clinical applications of whole blood flow cytometric assays of platelet function in these diseases may include identification of patients who would benefit from additional antiplatelet therapy and prediction of ischemic events. Circulating monocyte-platelet aggregates appear to be a more sensitive marker of in vivo platelet activation than circulating P-selectin-positive platelets. Flow cytometry can also be used in the following clinical settings: monitoring of glycoprotein IIb-IIIa antagonist therapy, diagnosis of inherited deficiencies of platelet surface glycoproteins, diagnosis of storage pool disease, diagnosis of heparin-induced thrombocytopenia, and measurement of the rate of thrombopoiesis.
    Source
    Curr Opin Hematol. 1999 Sep;6(5):342-8.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43339
    PubMed ID
    10468151
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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