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dc.contributor.authorMichelson, Alan D.
dc.date2022-08-11T08:10:10.000
dc.date.accessioned2022-08-23T16:58:19Z
dc.date.available2022-08-23T16:58:19Z
dc.date.issued1998-06-01
dc.date.submitted2012-04-25
dc.identifier.citationSemin Thromb Hemost. 1998;24(6):507-12. doi 10.1055/s-2007-996049
dc.identifier.issn0094-6176 (Linking)
dc.identifier.doi10.1055/s-2007-996049
dc.identifier.pmid10066145
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43341
dc.description.abstractWhole blood flow cytometry, an important new method for the assessment of platelet function, is particularly advantageous for neonatal studies because only minuscule volumes (approximately 2 microL) of blood are required. By this method, we have demonstrated that neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood, as determined by the activation-induced increase in the platelet surface expression of P-selectin and the glycoprotein (GP) IIb-IIIa complex and by the activation-induced decrease in the platelet surface expression of the GPIb-IX complex. Our data suggest that the mechanism of neonatal platelet hyporeactivity is, at least in part, a relative defect in a common signal transduction pathway. We have further demonstrated that the platelets of very low birth weight (VLBW) preterm neonates are maximally hyporeactive on days 3 to 4 of life but return to almost the adult range by days 10 to 14. Given that intraventricular hemorrhage (IVH) is also maximal on days 3 to 4, these defects may contribute to the propensity of VLBW preterm neonates to IVH.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10066145&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1055/s-2007-996049
dc.subjectAnimals
dc.subjectBlood Platelets
dc.subjectFlow Cytometry
dc.subjectHumans
dc.subjectInfant, Newborn
dc.subjectPlatelet Function Tests
dc.subjectHematology
dc.subjectOncology
dc.subjectPediatrics
dc.titlePlatelet function in the newborn
dc.typeJournal Article
dc.source.journaltitleSeminars in thrombosis and hemostasis
dc.source.volume24
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_hematology/2
dc.identifier.contextkey2796489
html.description.abstract<p>Whole blood flow cytometry, an important new method for the assessment of platelet function, is particularly advantageous for neonatal studies because only minuscule volumes (approximately 2 microL) of blood are required. By this method, we have demonstrated that neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood, as determined by the activation-induced increase in the platelet surface expression of P-selectin and the glycoprotein (GP) IIb-IIIa complex and by the activation-induced decrease in the platelet surface expression of the GPIb-IX complex. Our data suggest that the mechanism of neonatal platelet hyporeactivity is, at least in part, a relative defect in a common signal transduction pathway. We have further demonstrated that the platelets of very low birth weight (VLBW) preterm neonates are maximally hyporeactive on days 3 to 4 of life but return to almost the adult range by days 10 to 14. Given that intraventricular hemorrhage (IVH) is also maximal on days 3 to 4, these defects may contribute to the propensity of VLBW preterm neonates to IVH.</p>
dc.identifier.submissionpathpeds_hematology/2
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages507-12


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