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    Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease

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    Authors
    Furman, Mark I.
    Benoit, Stephen E.
    Barnard, Marc R.
    Valeri, C. Robert
    Borbone, Marie L.
    Becker, Richard C.
    Hechtman, Herbert B.
    Michelson, Alan D.
    UMass Chan Affiliations
    Department of Surgery
    Department of Pediatrics
    Department of Medicine
    Document Type
    Journal Article
    Publication Date
    1998-02-01
    Keywords
    Adenosine Diphosphate
    Adult
    Angina Pectoris
    Cell Adhesion
    Cell Adhesion Molecules
    Cell Count
    Cell Degranulation
    Cell Movement
    Coronary Artery Disease
    Coronary Disease
    Coronary Vessels
    Epinephrine
    Female
    Flow Cytometry
    Humans
    Leukocytes
    Male
    Middle Aged
    Monocytes
    P-Selectin
    Peptide Fragments
    Platelet Activation
    Platelet Aggregation
    Receptors, Thrombin
    Thrombosis
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1016/S0735-1097(97)00510-X
    Abstract
    OBJECTIVES: We sought to examine whether patients with stable coronary artery disease (CAD) have increased platelet reactivity and an enhanced propensity to form monocyte-platelet aggregates. BACKGROUND: Platelet-dependent thrombosis and leukocyte infiltration into the vessel wall are characteristic cellular events seen in atherosclerosis. METHODS: Anticoagulated peripheral venous blood from 19 patients with stable CAD and 19 normal control subjects was incubated with or without various platelet agonists and analyzed by whole blood flow cytometry. RESULTS: Circulating degranulated platelets were increased in patients with CAD compared with control subjects (mean [+/- SEM] percent P-selectin-positive platelets: 2.1 +/- 0.2 vs. 1.5 +/- 0.2, p andlt; 0.01) and were more reactive to stimulation with 1 micromol/liter of adenosine diphosphate (ADP) (28.7 +/- 3.9 vs. 16.1 +/- 2.2, p andlt; 0.01), 1 micromol/liter of ADP/epinephrine (51.4 +/- 4.6 vs. 37.5 +/- 3.8, p andlt; 0.05) or 5 micromol/liter of thrombin receptor agonist peptide (TRAP) (65.7 +/- 6.8 vs. 20.2 +/- 5.1, p andlt; 0.01). Patients with stable CAD also had increased circulating monocyte-platelet aggregates compared with control subjects (percent platelet-positive monocytes: 15.3 +/- 3.0 vs. 6.3 +/- 0.9, p andlt; 0.01). Furthermore, patients with stable CAD formed more monocyte-platelet aggregates than did control subjects when their whole blood was stimulated with 1 micromol/liter of ADP (50.4 +/- 4.5 vs. 28.1 +/- 5.3, p andlt; 0.01), 1 micromol/liter of ADP/epinephrine (60.7 +/- 4.3 vs. 48.0 +/- 4.8, p andlt; 0.05) or 5 micromol/liter of TRAP (67.6 +/- 5.7 vs. 34.3 +/- 7.0, p andlt; 0.01). CONCLUSIONS: Patients with stable CAD have circulating activated platelets, circulating monocyte-platelet aggregates, increased platelet reactivity and an increased propensity to form monocyte-platelet aggregates.
    Source
    J Am Coll Cardiol. 1998 Feb;31(2):352-8. doi 10.1016/S0735-1097(97)00510-X
    DOI
    10.1016/S0735-1097(97)00510-X
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43362
    PubMed ID
    9462579
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0735-1097(97)00510-X
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