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    GPIIb-IIIa antagonists reduce thromboinflammatory processes in patients with acute coronary syndromes undergoing percutaneous coronary intervention

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    Authors
    Furman, Mark I.
    Krueger, Lori A.
    Linden, Matthew Dean
    Fox, Marsha L.
    Ball, Steven P.
    Barnard, Marc R.
    Frelinger, Andrew L. III
    Michelson, Alan D.
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2005-02-01
    Keywords
    Acute Disease
    Aged
    Angioplasty, Balloon, Coronary
    Antibodies, Monoclonal
    Blood Platelets
    CD40 Ligand
    Coronary Disease
    Female
    Humans
    Immunoglobulin Fab Fragments
    Inflammation
    Leukocytes
    Male
    Middle Aged
    Platelet Adhesiveness
    Platelet Aggregation Inhibitors
    Platelet Glycoprotein GPIIb-IIIa Complex
    Ticlopidine
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1111/j.1538-7836.2005.01124.x
    Abstract
    OBJECTIVE: To investigate the effects of abciximab, eptifibatide and no GPIIb-IIIa antagonist (control) on soluble CD40 ligand (sCD40L) and the formation of leukocyte-platelet aggregates (LPA) in 98 ACS patients undergoing percutaneus coronary intervention (PCI). BACKGROUND: sCD40L and LPA are increased in patients with ACS. METHODS: sCD40L was measured by enzyme-linked immunosorbent assay (ELISA) and LPA by whole blood flow cytometry. RESULTS: There were no baseline differences between the three groups in sCD40L and LPA. At the end of PCI, sCD40L was unchanged in the controls, decreased by 30% (P andlt; 0.001) in the abciximab group and by 11% (P andlt; 0.02) in the eptifibatide group. Eighteen to 24 h after PCI, sCD40L was unchanged in the controls, reduced 30% (P andlt; 0.001) in the abciximab-treated group and 9% (P andlt; 0.01) in the eptifibatide-treated group. At the end of PCI, circulating monocyte-platelet aggregates (MPA) were reduced by 12% (P = NS) in the abciximab-treated group, 13% in the eptifibatide-treated group (P = NS), but slightly increased in the controls (P = NS). Eighteen to 24 h after PCI, MPA were reduced by 41% (P andlt; 0.001) compared to baseline in the abciximab-treated group, by 23% (P = NS) in the eptifibatide-treated group, and 15% (P = NS) in the controls. In contrast to control patients presenting while on clopidogrel, control patients presenting not on clopidogrel demonstrated a reduction in sCD40L and LPA 18-24 h post-PCI (P = NS). At low receptor occupancy, GPIIb-IIIa antagonists did not augment the release of sCD40L or the number of circulating LPA. CONCLUSIONS: GPIIb-IIIa antagonists reduce circulating sCD40L and LPA formation in patients with ACS undergoing PCI. At low receptor occupancy, GPIIb-IIIa antagonists do not activate platelets.
    Source
    J Thromb Haemost. 2005 Feb;3(2):312-20. doi 10.1111/j.1538-7836.2005.01124.x
    DOI
    10.1111/j.1538-7836.2005.01124.x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43378
    PubMed ID
    15670038
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1538-7836.2005.01124.x
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