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    Role of iodine-131 MIBG scanning in the management of paediatric patients with neuroblastoma

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    Authors
    Shah Syed, G. M.
    Naseer, H.
    Usmani, G. Naheed
    Cheema, M. A.
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2004-07-01
    Keywords
    3-Iodobenzylguanidine
    Child
    Child, Preschool
    Female
    Humans
    Infant
    Iodine Radioisotopes
    Male
    Neural Crest
    Neuroblastoma
    Radiopharmaceuticals
    Tomography, X-Ray Computed
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1159/000078315
    Abstract
    OBJECTIVES: To evaluate the role of iodine-131 metoiodobenzylguanidine (iodine-131 MIBG) scanning in the management of paediatric patients with neuroblastoma. SUBJECTS AND METHODS: Forty-three iodine-131 MIBG scans were performed on 26 children, 18 male and 8 female, ranging in age from 8 months to 11 years. Bone scan, computed tomography (CT) images and findings of bone marrow biopsy were compared with the iodine-131 MIBG scan findings. RESULTS: Of the 26 patients, 18 (69%) showed abnormal iodine-131 MIBG avidity and were proven to have a neural crest tumour on histology. The remaining 8 (31%) patients had normal iodine-131 MIBG scans, and histology showed a malignancy other than a neural crest tumour. Iodine-131 MIBG scans showed the primary site in 16 of 17 patients while CT showed 14 primary sites. In follow-up studies, the results were as follows: iodine-131 MIBG showed no evidence of disease in 4 compared with 3 on CT, persistent disease in 2 on iodine-131 MIBG and 4 on CT; recurrence in 1 on iodine-131 MIBG and 0 on CT; MIBG scans detected double the number of bony lesions compared with bone scans. The findings on iodine-131 MIBG scans and bone marrow biopsy were in agreement in 16/18 cases. Patients in whom iodine-131 MIBG scans showed disease resolution had better clinical outcomes. CONCLUSION: The findings indicate that iodine-131 MIBG scanning is useful for the diagnosis, staging, evaluation of response to therapy and detection of recurrences in patients with neuroblastoma. It exhibited a clear advantage over CT in detecting the primary site and soft issue metastases and was also superior to bone scanning in detecting skeletal metastases. It also reliably demonstrated bone marrow involvement.
    Source
    Med Princ Pract. 2004 Jul-Aug;13(4):196-200. doi 10.1159/000078315
    DOI
    10.1159/000078315
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43380
    PubMed ID
    15181323
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1159/000078315
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