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    Application of flow cytometry to platelet disorders

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    Authors
    Linden, Matthew Dean
    Frelinger, Andrew L. III
    Barnard, Marc R.
    Przyklenk, Karin
    Furman, Mark I.
    Michelson, Alan D.
    UMass Chan Affiliations
    Department of Anesthesiology
    Department of Emergency Medicine
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2004-10-01
    Keywords
    Blood Platelet Disorders
    Blood Platelets
    Coronary Disease
    Flow Cytometry
    Humans
    Phenotype
    Platelet Activation
    Syndrome
    Thrombocytopenia
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1055/s-2004-835671
    Abstract
    Flow cytometry is a powerful and versatile tool that can be used to yield definitive information regarding the phenotypic status of platelets. The method provides a quantitative assessment of the physical and antigenic properties of platelets (e.g., surface expression of receptors, bound ligands, components of granules, or interactions of platelets with other platelets, other blood cells, or components of the plasma coagulation system), thereby facilitating the diagnosis of inherited or acquired platelet disorders (e.g., Bernard-Soulier syndrome, Glanzmann thrombasthenia, storage pool disease), the pathological activation of platelets (e.g., in the setting of acute coronary syndromes, cerebrovascular ischemia, peripheral vascular disease, cardiopulmonary bypass), and changes in the ability of platelets to activate via specific stimuli (e.g., efficacy of antiplatelet therapies). Accordingly, this review summarizes the key technical and methodologic components of flow cytometric analysis of platelets, as well as specific examples of its application to diagnosis and patient care.
    Source
    Semin Thromb Hemost. 2004 Oct;30(5):501-11. doi 10.1055/s-2004-835671
    DOI
    10.1055/s-2004-835671
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43381
    PubMed ID
    15497093
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1055/s-2004-835671
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    UMass Chan Faculty and Researcher Publications
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