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    A panorama of lineage-specific transcription in hematopoiesis

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    Authors
    Kluger, Yuval
    Lian, Zheng
    Zhang, Xueqing
    Newburger, Peter E.
    Weissman, Sherman M.
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2004-12-01
    Keywords
    Animals
    Cell Differentiation
    Cell Lineage
    Gene Expression Profiling
    *Gene Expression Regulation, Developmental
    Hematopoiesis
    Hematopoietic Stem Cells
    Humans
    Transcription Factors
    *Transcription, Genetic
    Hematology
    Oncology
    Pediatrics
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    http://dx.doi.org/10.1002/bies.20144
    Abstract
    The hematopoietic system consists of more than ten differentiated cell types, all of which are derived from a single type of hematopoietic stem cell. The accessibility and interest of this system have made it a model for understanding normal and abnormal differentiation of mammalian cells. Newer techniques have generated a mass of data that requires integrative approaches for analysis and interpretation. The traditional view of the differentiation program holds that a small number of regulators are involved in each stage of cell specification. However, this may not be the case. Recent analyses have shown that almost all substantial subsets of genes, including the set of broadly expressed transcription factors, are expressed in patterns that are unique for each lineage. Further, much of this difference between lineages can be captured in two-dimensional graphs. Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike.
    Source
    Bioessays. 2004 Dec;26(12):1276-87. doi 10.1002/bies.20144
    DOI
    10.1002/bies.20144
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43384
    PubMed ID
    15551261
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/bies.20144
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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