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dc.contributor.authorKluger, Yuval
dc.contributor.authorLian, Zheng
dc.contributor.authorZhang, Xueqing
dc.contributor.authorNewburger, Peter E.
dc.contributor.authorWeissman, Sherman M.
dc.date2022-08-11T08:10:10.000
dc.date.accessioned2022-08-23T16:58:31Z
dc.date.available2022-08-23T16:58:31Z
dc.date.issued2004-12-01
dc.date.submitted2012-04-25
dc.identifier.citationBioessays. 2004 Dec;26(12):1276-87. doi 10.1002/bies.20144
dc.identifier.issn0265-9247 (Linking)
dc.identifier.doi10.1002/bies.20144
dc.identifier.pmid15551261
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43384
dc.description.abstractThe hematopoietic system consists of more than ten differentiated cell types, all of which are derived from a single type of hematopoietic stem cell. The accessibility and interest of this system have made it a model for understanding normal and abnormal differentiation of mammalian cells. Newer techniques have generated a mass of data that requires integrative approaches for analysis and interpretation. The traditional view of the differentiation program holds that a small number of regulators are involved in each stage of cell specification. However, this may not be the case. Recent analyses have shown that almost all substantial subsets of genes, including the set of broadly expressed transcription factors, are expressed in patterns that are unique for each lineage. Further, much of this difference between lineages can be captured in two-dimensional graphs. Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15551261&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/bies.20144
dc.subjectAnimals
dc.subjectCell Differentiation
dc.subjectCell Lineage
dc.subjectGene Expression Profiling
dc.subject*Gene Expression Regulation, Developmental
dc.subjectHematopoiesis
dc.subjectHematopoietic Stem Cells
dc.subjectHumans
dc.subjectTranscription Factors
dc.subject*Transcription, Genetic
dc.subjectHematology
dc.subjectOncology
dc.subjectPediatrics
dc.titleA panorama of lineage-specific transcription in hematopoiesis
dc.typeArticle
dc.source.journaltitleBioEssays : news and reviews in molecular, cellular and developmental biology
dc.source.volume26
dc.source.issue12
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_hematology/61
dc.identifier.contextkey2796551
html.description.abstract<p>The hematopoietic system consists of more than ten differentiated cell types, all of which are derived from a single type of hematopoietic stem cell. The accessibility and interest of this system have made it a model for understanding normal and abnormal differentiation of mammalian cells. Newer techniques have generated a mass of data that requires integrative approaches for analysis and interpretation. The traditional view of the differentiation program holds that a small number of regulators are involved in each stage of cell specification. However, this may not be the case. Recent analyses have shown that almost all substantial subsets of genes, including the set of broadly expressed transcription factors, are expressed in patterns that are unique for each lineage. Further, much of this difference between lineages can be captured in two-dimensional graphs. Understanding the biologic significance, mechanisms and constraints underlying these differences is a challenge for experimentalists and computational biologists alike.</p>
dc.identifier.submissionpathpeds_hematology/61
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages1276-87


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