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    The role of toll-like receptors in herpes simplex infection in neonates

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    Authors
    Kurt-Jones, Evelyn A.
    Belko, John
    Yu, Catherine
    Newburger, Peter E.
    Wang, Jennifer P.
    Chan, Melvin
    Knipe, David M.
    Finberg, Robert W.
    UMass Chan Affiliations
    Department of Medicine
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2005-03-01
    Keywords
    Adult
    Age Factors
    Cells, Cultured
    Cytokines
    Herpes Simplex
    Herpesvirus 1, Human
    Herpesvirus 2, Human
    Humans
    Infant, Newborn
    Interleukin-6
    Interleukin-8
    Leukocytes, Mononuclear
    Membrane Glycoproteins
    Receptors, Cell Surface
    Toll-Like Receptor 2
    Toll-Like Receptors
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1086/427339
    Abstract
    Toll-like receptors (TLRs)--and their associated signal-transducing proteins--on the surface of cells have been demonstrated to account for most, if not all, of the events associated with bacterial sepsis. Using human cells expressing different TLRs, we demonstrated that the interaction between TLR2 and herpes simplex virus (HSV)-1-2 leads to the production of cytokines. Using peripheral-blood mononuclear cells, we tested the ability of cells from people of different age groups to make cytokines in response to HSV. An examination of the host responses of neonates to HSV indicates that, rather than producing less interleukin-6 and interleukin-8 in response to HSV than adults do, neonates produce more of these cytokines than adults do. This may explain the sepsis syndrome that is seen with HSV (and other virus infections) in neonates.
    Source
    J Infect Dis. 2005 Mar 1;191(5):746-8. Epub 2005 Jan 18. doi: 10.1086/427339
    DOI
    10.1086/427339
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43396
    PubMed ID
    15688290
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1086/427339
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    UMass Chan Faculty and Researcher Publications

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