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    Frequency of aspirin resistance in a community hospital

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    Authors
    Mirkhel, Ahmadshah
    Peyster, Eliot
    Sundeen, James
    Greene, Linda
    Michelson, Alan D.
    Hasan, Ahmed
    Domanski, Michael
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2006-09-01
    Keywords
    Adult
    Aged
    Aged, 80 and over
    Aspirin
    *Drug Resistance
    Female
    Hospitals, Community
    Humans
    Incidence
    Male
    Maryland
    Middle Aged
    Platelet Aggregation Inhibitors
    Prognosis
    Retrospective Studies
    Thrombosis
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1016/j.amjcard.2006.03.029
    Abstract
    Aspirin resistance and its predictors were studied in community hospital patients who required antiplatelet therapy for thrombotic event prophylaxis. Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System with > or = 550 aspirin reaction units (ARUs) used as a dichotomous indicator of aspirin resistance. Patients (n = 123) were 21 to 95 years old; 49.6% were women, 77.2% were black, 95.1% were hypertensive, 85.4% had coronary disease, and 30.1% were smokers. ARU score for 325 versus 81 mg/day was 435.2 +/- 93.7 versus 401.9 +/- 83.9 ARU (p = 0.04), with a 12.1% (8 of 66 patients) nonresponse rate to 81 mg/day. Of the 8 patients who were unresponsive to 81 mg/day of aspirin, 7 responded to 325 mg/day. The 5.3% (3 of 57 patients) who were resistant to 325 mg/day received clopidogrel; 2 became responders. Multivariate analysis demonstrated significant associations of aspirin resistance with smoking (risk ratio 11.47, 95% confidence interval 6.69 to 18.63, p andlt; 0.0001), including a significant interaction between smoking and aspirin resistance. In conclusion, this study estimates aspirin resistance prevalence and shows a strong association of smoking with platelet hyperactivity in a diverse community hospital population. Nonresponders to 81 mg/day frequently responded to 325 mg/day or to the addition of clopidogrel.
    Source
    Am J Cardiol. 2006 Sep 1;98(5):577-9. Epub 2006 Jun 30. doi: 10.1016/j.amjcard.2006.03.029
    DOI
    10.1016/j.amjcard.2006.03.029
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43399
    PubMed ID
    16923439
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.amjcard.2006.03.029
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