Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Authors
Mirkhel, AhmadshahPeyster, Eliot
Sundeen, James
Greene, Linda
Michelson, Alan D.
Hasan, Ahmed
Domanski, Michael
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2006-09-01Keywords
AdultAged
Aged, 80 and over
Aspirin
*Drug Resistance
Female
Hospitals, Community
Humans
Incidence
Male
Maryland
Middle Aged
Platelet Aggregation Inhibitors
Prognosis
Retrospective Studies
Thrombosis
Hematology
Oncology
Pediatrics
Metadata
Show full item recordAbstract
Aspirin resistance and its predictors were studied in community hospital patients who required antiplatelet therapy for thrombotic event prophylaxis. Demographic and antiplatelet medication data were collected and medication response followed. Aspirin resistance was assayed with the VerifyNow System with > or = 550 aspirin reaction units (ARUs) used as a dichotomous indicator of aspirin resistance. Patients (n = 123) were 21 to 95 years old; 49.6% were women, 77.2% were black, 95.1% were hypertensive, 85.4% had coronary disease, and 30.1% were smokers. ARU score for 325 versus 81 mg/day was 435.2 +/- 93.7 versus 401.9 +/- 83.9 ARU (p = 0.04), with a 12.1% (8 of 66 patients) nonresponse rate to 81 mg/day. Of the 8 patients who were unresponsive to 81 mg/day of aspirin, 7 responded to 325 mg/day. The 5.3% (3 of 57 patients) who were resistant to 325 mg/day received clopidogrel; 2 became responders. Multivariate analysis demonstrated significant associations of aspirin resistance with smoking (risk ratio 11.47, 95% confidence interval 6.69 to 18.63, p andlt; 0.0001), including a significant interaction between smoking and aspirin resistance. In conclusion, this study estimates aspirin resistance prevalence and shows a strong association of smoking with platelet hyperactivity in a diverse community hospital population. Nonresponders to 81 mg/day frequently responded to 325 mg/day or to the addition of clopidogrel.Source
Am J Cardiol. 2006 Sep 1;98(5):577-9. Epub 2006 Jun 30. doi: 10.1016/j.amjcard.2006.03.029DOI
10.1016/j.amjcard.2006.03.029Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43399PubMed ID
16923439Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.amjcard.2006.03.029