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UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2006-03-01Keywords
Cardiac Surgical ProceduresChild
Child, Preschool
Humans
Infant
Mucocutaneous Lymph Node Syndrome
Platelet Activation
Platelet Aggregation Inhibitors
Stroke
Thrombosis
Hematology
Oncology
Pediatrics
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Show full item recordAbstract
Platelets are essential for the maintenance of vascular integrity and control of bleeding at sites of injury, but they are also implicated in the progression of atherosclerotic lesions and arterial vascular thrombosis. The use of antiplatelet drugs for the primary and secondary prevention of cardiovascular and cerebrovascular thromboses in adult populations has been extensively evaluated, resulting in defined management strategies. Much less is known about the appropriate use of antiplatelet drugs (primarily aspirin) in infants and children for secondary prevention in ischemic stroke, for prevention of coronary artery thrombosis in Kawasaki disease, or for prevention of thromboembolism following surgery for congenital cardiac disease. Additional studies will be required to evaluate the relative benefits of aspirin and anticoagulants in these settings. A role for newer antiplatelet drugs in the management of pediatric arterial thrombosis is as yet unexplored.Source
Thromb Res. 2006;118(1):75-83. Epub 2005 Feb 1. doi: 10.1016/j.thromres.2004.12.016DOI
10.1016/j.thromres.2004.12.016Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43402PubMed ID
16709476Related Resources
Link to article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.thromres.2004.12.016