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    Antiplatelet therapy in children

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    Authors
    Israels, Sara J.
    Michelson, Alan D.
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2006-03-01
    Keywords
    Cardiac Surgical Procedures
    Child
    Child, Preschool
    Humans
    Infant
    Mucocutaneous Lymph Node Syndrome
    Platelet Activation
    Platelet Aggregation Inhibitors
    Stroke
    Thrombosis
    Hematology
    Oncology
    Pediatrics
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    Link to Full Text
    http://dx.doi.org/10.1016/j.thromres.2004.12.016
    Abstract
    Platelets are essential for the maintenance of vascular integrity and control of bleeding at sites of injury, but they are also implicated in the progression of atherosclerotic lesions and arterial vascular thrombosis. The use of antiplatelet drugs for the primary and secondary prevention of cardiovascular and cerebrovascular thromboses in adult populations has been extensively evaluated, resulting in defined management strategies. Much less is known about the appropriate use of antiplatelet drugs (primarily aspirin) in infants and children for secondary prevention in ischemic stroke, for prevention of coronary artery thrombosis in Kawasaki disease, or for prevention of thromboembolism following surgery for congenital cardiac disease. Additional studies will be required to evaluate the relative benefits of aspirin and anticoagulants in these settings. A role for newer antiplatelet drugs in the management of pediatric arterial thrombosis is as yet unexplored.
    Source
    Thromb Res. 2006;118(1):75-83. Epub 2005 Feb 1. doi: 10.1016/j.thromres.2004.12.016
    DOI
    10.1016/j.thromres.2004.12.016
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43402
    PubMed ID
    16709476
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.thromres.2004.12.016
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