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dc.contributor.authorNakayama, Yasuhiro
dc.contributor.authorStabach, Paul
dc.contributor.authorMaher, Stephen E.
dc.contributor.authorMahajan, Milind C.
dc.contributor.authorMasiar, Peter
dc.contributor.authorLiao, Cheng
dc.contributor.authorZhang, Xueqing
dc.contributor.authorYe, Zhi-jia
dc.contributor.authorTuck, David
dc.contributor.authorBothwell, Alfred L.M.
dc.contributor.authorNewburger, Peter E.
dc.contributor.authorWeissman, Sherman M.
dc.date2022-08-11T08:10:11.000
dc.date.accessioned2022-08-23T16:58:37Z
dc.date.available2022-08-23T16:58:37Z
dc.date.issued2006-12-01
dc.date.submitted2012-04-25
dc.identifier.citationJ Cell Biochem. 2006 Dec 1;99(5):1308-25. doi: 10.1002/jcb.20952
dc.identifier.issn0730-2312 (Linking)
dc.identifier.doi10.1002/jcb.20952
dc.identifier.pmid16795035
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43409
dc.description.abstractMature B cells, upon activation, progressively differentiate through centroblasts into centrocytes and finally to plasmacytes that express large amounts of selected immunoglobulins. A significant part of this maturation is thought to involve induction of the unfolded protein response (UPR). We have compared gene expression in normal germinal center centroblasts, centrocytes, lymphoblastoid cells undergoing induced UPR, and the CCL155 plasmacytoma cell line. In the centroblast to centrocyte transition there is a change in the expression of a relatively small number of genes. These include a limited subset of the genes upregulated by a fully activated UPR as well as a small number of other transcription factors, some disulphide isomerases, and other genes. This is consistent with a model in which this transition is mediated by changes in the levels of expression of transcription factor B-lymphocyte-induced maturation protein 1 (Blimp1) (PRDM1), BACH2, X-box binding protein 1 (XBP1), interferon regulatory factor 4 (IRF4), and possibly vitamin D receptor (VDR) expression, together with post-transcriptional changes and a limited induction of aspects of the UPR.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16795035&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/jcb.20952
dc.subjectAnimals
dc.subjectB-Lymphocytes
dc.subjectCell Differentiation
dc.subjectCell Line
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectDNA-Binding Proteins
dc.subjectDithiothreitol
dc.subjectGene Expression Profiling
dc.subjectGerminal Center
dc.subjectHumans
dc.subjectMolecular Sequence Data
dc.subjectNuclear Proteins
dc.subjectOligonucleotide Array Sequence Analysis
dc.subjectPalatine Tonsil
dc.subjectProtein Folding
dc.subjectTranscription Factors
dc.subjectTunicamycin
dc.subjectHematology
dc.subjectOncology
dc.subjectPediatrics
dc.titleA limited number of genes are involved in the differentiation of germinal center B cells
dc.typeJournal Article
dc.source.journaltitleJournal of cellular biochemistry
dc.source.volume99
dc.source.issue5
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_hematology/87
dc.identifier.contextkey2796577
html.description.abstract<p>Mature B cells, upon activation, progressively differentiate through centroblasts into centrocytes and finally to plasmacytes that express large amounts of selected immunoglobulins. A significant part of this maturation is thought to involve induction of the unfolded protein response (UPR). We have compared gene expression in normal germinal center centroblasts, centrocytes, lymphoblastoid cells undergoing induced UPR, and the CCL155 plasmacytoma cell line. In the centroblast to centrocyte transition there is a change in the expression of a relatively small number of genes. These include a limited subset of the genes upregulated by a fully activated UPR as well as a small number of other transcription factors, some disulphide isomerases, and other genes. This is consistent with a model in which this transition is mediated by changes in the levels of expression of transcription factor B-lymphocyte-induced maturation protein 1 (Blimp1) (PRDM1), BACH2, X-box binding protein 1 (XBP1), interferon regulatory factor 4 (IRF4), and possibly vitamin D receptor (VDR) expression, together with post-transcriptional changes and a limited induction of aspects of the UPR.</p>
dc.identifier.submissionpathpeds_hematology/87
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages1308-25


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