Indices of platelet activation and the stability of coronary artery disease
AuthorsLinden, Matthew Dean
Furman, Mark I.
Frelinger, Andrew L. III
Fox, Marsha L.
Barnard, Marc R.
Michelson, Alan D.
UMass Chan AffiliationsDepartment of Anesthesiology
Department of Emergency Medicine
Department of Pediatrics
Document TypeJournal Article
Anti-Inflammatory Agents, Non-Steroidal
Coronary Artery Disease
Platelet Function Tests
Platelet Glycoprotein GPIIb-IIIa Complex
MetadataShow full item record
AbstractAIM: To determine whether indices of platelet activation are associated with the stability of coronary artery disease (CAD). METHODS: Platelet function was examined in 677 consecutive aspirin-treated patients presenting for cardiac catheterization. Patients were grouped into recent myocardial infarction (MI), no MI but angiographically documented CAD (non-MI CAD) and no angiographically detectible CAD (no CAD), as well as additional subgroups. RESULTS: Compared with non-MI CAD or no CAD patients, more patients with recent MI had a shortened platelet function analyzer (PFA)-100 collagen-epinephrine closure time (CT) and increased circulating monocyte-platelet aggregates, neutrophil-platelet aggregates, activated platelet surface GPIIb-IIIa and plasma soluble CD40 ligand (sCD40L). More patients with non-MI CAD had shortened PFA-100 CTs and increased monocyte-platelet aggregates compared with patients with no CAD. Platelet surface P-selectin did not differ among the groups. Subgroup analysis revealed that decreasing PFA-100 CT correlated with the stability of CAD. CONCLUSIONS: Indices of platelet activation, especially the PFA-100 CT, are associated with the stability of CAD, and may reflect plaque instability, an ongoing thrombotic state and/or reduced responsiveness to aspirin.
SourceJ Thromb Haemost. 2007 Apr;5(4):761-5. Epub 2007 Feb 26. doi: 10.1111/j.1538-7836.2007.02462.x
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/43416
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