Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort
Authors
Greenough, Thomas C.Brettler, Doreen B.
Kirchhoff, Frank
Alexander, Louis
Desrosiers, Ronald C.
O'Brien, Stephen J.
Somasundaran, Mohan
Luzuriaga, Katherine
Sullivan, John L.
UMass Chan Affiliations
Department of Medicine, Division of Hematology/OncologyProgram in Molecular Medicine
Department of Pediatrics
Document Type
Journal ArticlePublication Date
1999-12-01Keywords
CD4 Lymphocyte CountChemokines
Cohort Studies
*HIV Infections
*HIV Long-Term Survivors
HIV-1
Hemophilia A
Humans
Immunophenotyping
Lymphocyte Activation
Polymerase Chain Reaction
Polymorphism, Genetic
Receptors, Chemokine
T-Lymphocytes
T-Lymphocytes, Cytotoxic
Viral Load
Virus Replication
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
Seven long-term nonprogressors (LTNPs) have been identified in a cohort of 128 human immunodeficiency virus (HIV)-1 infected individuals with hemophilia. Studies included quantitation of virus by polymerase chain reaction, characterization of primary virus isolates in vitro, analysis of lymphocyte surface markers, and measurement of virus-specific cytotoxic T lymphocytes (CTLs). Viruses of LTNPs exhibited slow growth in vivo and in vitro. LTNPs had expansion of CD8 T cells with increased expression of HLA-DR. Intermittent HIV-1-specific CTL effector activity was detected in freshly isolated peripheral blood mononuclear cells of most LTNPs. CTL precursor frequencies were higher in LTNPs than in patients with progressive disease. Virus antigen-specific lymphoproliferation was vigorous in some LTNPs. Thus, LTNPs in this cohort have maintained remarkably low virus burdens and vigorous HIV-1-specific cell-mediated immunity over a 15-year period. The presence of expanded, activated CD8 T cells with cytotoxic effector function in the peripheral blood suggests ongoing viral replication.Source
J Infect Dis. 1999 Dec;180(6):1790-802. Link to article on publisher's siteDOI
10.1086/315128Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43425PubMed ID
10558933Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/315128