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    Pharmacokinetics of nevirapine in human immunodeficiency virus type 1-infected pregnant women and their neonates. Pediatric AIDS Clinical Trials Group Protocol 250 Team

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    Authors
    Mirochnick, Mark
    Fenton, Terry
    Gagnier, Paul
    Pav, Joseph W.
    Gwynne, Meg
    Siminski, Sue
    Sperling, Rhoda S.
    Beckerman, Karen
    Jimenez, Eleanor
    Yogev, Ram
    Spector, Stephen A.
    Sullivan, John L.
    Show allShow less
    UMass Chan Affiliations
    Program in Molecular Medicine
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    1998-08-01
    Keywords
    Adult
    Anti-HIV Agents
    Cohort Studies
    Female
    Follow-Up Studies
    HIV Infections
    *HIV-1
    Humans
    Infant
    Infant, Newborn
    Nevirapine
    Pregnancy
    Pregnancy Complications, Infectious
    Reverse Transcriptase Inhibitors
    effects
    Immunology and Infectious Disease
    Pediatrics
    Show allShow less
    
    Metadata
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    Link to Full Text
    http://dx.doi.org/10.1086/515641
    Abstract
    The safety, toxicity, and pharmacokinetics of intrapartum and early newborn nevirapine were evaluated in 17 human immunodeficiency virus type 1-infected women in labor and their newborns. No adverse effects of nevirapine were noted in any study mothers or infants. Following maternal dosing with 200 mg during labor, concentrations exceeding 100 ng/mL (10 times the in vitro IC50) were achieved in the newborns. Nevirapine elimination was prolonged in both mothers and infants, with median half-lives ranging from 36.8 to 65.7 h. Administration of 200 mg orally to the mothers in labor and of a single 2-mg/kg oral dose to the infants at 48-72 h after birth maintained serum concentrations in the infants > 100 ng/mL through 7 days of life.
    Source
    J Infect Dis. 1998 Aug;178(2):368-74.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43435
    PubMed ID
    9697716
    Related Resources
    Link to Article in PubMed
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    UMass Chan Faculty and Researcher Publications

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