Alterations in HIV-1 LTR promoter activity during AIDS progression
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Authors
Hiebenthal-Millow, KirstenGreenough, Thomas C.
Bretttler, Doreen B.
Schindler, Michael
Wildum, Steffen
Sullivan, John L.
Kirchhoff, Frank
Document Type
Journal ArticlePublication Date
2003-12-05Keywords
AdolescentAdult
Base Sequence
Cell Line
Child
Child, Preschool
Disease Progression
HIV Infections
HIV Long Terminal Repeat
HIV-1
Humans
Jurkat Cells
Leukocytes, Mononuclear
Middle Aged
Molecular Sequence Data
*Mutation
Promoter Regions, Genetic
U937 Cells
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
HIV-1 variants evolving in AIDS patients frequently show increased replicative capacity compared to those present during early asymptomatic infection. It is known that late stage HIV-1 variants often show an expanded coreceptor tropism and altered Nef function. In the present study we investigated whether enhanced HIV-1 LTR promoter activity might also evolve during disease progression. Our results demonstrate increased LTR promoter activity after AIDS progression in 3 of 12 HIV-1-infected individuals studied. Further analysis revealed that multiple alterations in the U3 core-enhancer and in the transactivation-response (TAR) region seem to be responsible for the enhanced functional activity. Our findings show that in a subset of HIV-1-infected individuals enhanced LTR transcription contributes to the increased replicative potential of late stage virus isolates and might accelerate disease progression.Source
Virology. 2003 Dec 5;317(1):109-18. doi:10.1016/j.virol.2003.08.034DOI
10.1016/j.virol.2003.08.034Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43450PubMed ID
14675629Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.virol.2003.08.034