Alterations in HIV-1 LTR promoter activity during AIDS progression
Greenough, Thomas C.
Bretttler, Doreen B.
Sullivan, John L.
Document TypeJournal Article
HIV Long Terminal Repeat
Molecular Sequence Data
Promoter Regions, Genetic
Immunology and Infectious Disease
MetadataShow full item record
AbstractHIV-1 variants evolving in AIDS patients frequently show increased replicative capacity compared to those present during early asymptomatic infection. It is known that late stage HIV-1 variants often show an expanded coreceptor tropism and altered Nef function. In the present study we investigated whether enhanced HIV-1 LTR promoter activity might also evolve during disease progression. Our results demonstrate increased LTR promoter activity after AIDS progression in 3 of 12 HIV-1-infected individuals studied. Further analysis revealed that multiple alterations in the U3 core-enhancer and in the transactivation-response (TAR) region seem to be responsible for the enhanced functional activity. Our findings show that in a subset of HIV-1-infected individuals enhanced LTR transcription contributes to the increased replicative potential of late stage virus isolates and might accelerate disease progression.
SourceVirology. 2003 Dec 5;317(1):109-18. doi:10.1016/j.virol.2003.08.034
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/43450
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