A polymorphism in the regulatory region of the CC-chemokine receptor 5 gene influences perinatal transmission of human immunodeficiency virus type 1 to African-American infants
Authors
Kostrikis, Leondios G.Neumann, Avidan U.
Thomson, Bruce
Korber, Bette T.
McHardy, Paul
Karanicolas, Rose
Deutsch, Lisa
Huang, Yaoxing
Lew, Judy F.
McIntosh, Kenneth
Pollack, Henry
Borkowsky, William
Speigel, Hans M.
Palumbo, Paul
Oleske, James
Bardeguez, Arlene
Luzuriaga, Katherine
Sullivan, John L.
Wolinsky, Steven M.
Koup, Richard A.
Ho, David D.
Moore, John P.
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
1999-12-01Keywords
5' Untranslated RegionsAdult
*African Americans
Alleles
Anti-HIV Agents
Cohort Studies
European Continental Ancestry Group
Female
Gene Frequency
Genotype
HIV Infections
*HIV-1
Hispanic Americans
Humans
Infant
*Infectious Disease Transmission, Vertical
Linkage Disequilibrium
Perinatal Care
*Polymorphism, Genetic
Receptors, CCR2
Receptors, CCR5
*Receptors, Chemokine
Receptors, Cytokine
Regulatory Sequences, Nucleic Acid
Zidovudine
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
There are natural mutations in the coding and noncoding regions of the human immunodeficiency virus type 1 (HIV-1) CC-chemokine coreceptor 5 (CCR5) and in the related CCR2 protein (the CCR2-64I mutation). Individuals homozygous for the CCR5-Delta32 allele, which prevents CCR5 expression, strongly resist HIV-1 infection. Several genetic polymorphisms have been identified within the CCR5 5' regulatory region, some of which influence the rate of disease progression in adult AIDS study cohorts. We genotyped 1,442 infants (1,235 uninfected and 207 HIV-1 infected) for five CCR5 and CCR2 polymorphisms: CCR5-59353-T/C, CCR5-59356-C/T CCR5-59402-A/G, CCR5-Delta32, and CCR2-64I. The clinical significance of each genotype was assessed by measuring whether it influenced the rate of perinatal HIV-1 transmission among 667 AZT-untreated mother-infant pairs (554 uninfected and 113 HIV-1 infected). We found that the mutant CCR5-59356-T allele is relatively common in African-Americans (20.6% allele frequency among 552 infants) and rare in Caucasians and Hispanics (3.4 and 5.6% of 174 and 458 infants, respectively; P < 0.001). There were 38 infants homozygous for CCR5-59356-T, of whom 35 were African-Americans. Among the African-American infants in the AZT-untreated group, there was a highly significant increase in HIV-1 transmission to infants with two mutant CCR5-59356-T alleles (47.6% of 21), compared to those with no or one mutant allele (13.4 to 14.1% of 187 and 71, respectively; P < 0.001). The increased relative risk was 5.9 (95% confidence interval, 2.3 to 15.3; P < 0.001). The frequency of the CCR5-59356-T mutation varies between population groups in the United States, a low frequency occurring in Caucasians and a higher frequency occurring in African-Americans. Homozygosity for CCR5-59356-T is strongly associated with an increased rate of perinatal HIV-1 transmission.Source
J Virol. 1999 Dec;73(12):10264-71. Link to article on publisher's websitePermanent Link to this Item
http://hdl.handle.net/20.500.14038/43457PubMed ID
10559343Related Resources
Link to Article in PubMedCollections
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