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Immunogenicity and efficacy of childhood vaccines in HIV-1-infected children
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Document Type
Journal ArticlePublication Date
2004-08-01Keywords
Bacterial VaccinesChild, Preschool
HIV Infections
HIV-1
Humans
Immunologic Memory
Infant
*Vaccination
Vaccines, Attenuated
Vaccines, Subunit
Viral Vaccines
Virus Replication
Immunology and Infectious Disease
Pediatrics
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Show full item recordAbstract
Children infected by HIV-1 are particularly vulnerable to severe, recurrent, or unusual infections by vaccine-preventable pathogens. Routine immunisations seem to be generally safe for HIV-1-infected children, but responses may be suboptimal. Early HIV-1-induced immune attrition associated with viral replication may particularly interfere with the development of memory responses. In high HIV-1 prevalence regions, the accumulation of susceptible hosts may compromise disease-control efforts. Although early control of viral replication through treatment with highly active therapy may preserve immune function and responses to routine childhood vaccines, availability is limited in the areas most affected. In this review, we provide an overview of the immunogenicity and efficacy of childhood vaccines in HIV-1-infected children. The possible immunological bases for defective responses are discussed; unanswered questions and the need for further research are delineated.Source
Lancet Infect Dis. 2004 Aug;4(8):510-8. Link to article on publisher's siteDOI
10.1016/S1473-3099(04)01106-5Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43461PubMed ID
15288824Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/S1473-3099(04)01106-5
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