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    Therapy with a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody reduces disease severity and viral burden in golden Syrian hamsters

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    Authors
    Roberts, Anjeanette
    Thomas, William D.
    Guarner, Jeannette
    Lamirande, Elaine W.
    Babcock, Gregory J.
    Greenough, Thomas C.
    Vogel, Leatrice
    Hayes, Norman
    Sullivan, John L.
    Zaki, Sherif
    Subbarao, Kanta
    Ambrosino, Donna M.
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    UMass Chan Affiliations
    Massachusetts Biologic Laboratories
    Program in Molecular Medicine
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2006-03-01
    Keywords
    Animals
    Antibodies, Monoclonal
    Antibodies, Viral
    Cricetinae
    Disease Models, Animal
    Female
    Immunoglobulin G
    Immunotherapy
    Lung
    Lung Diseases, Interstitial
    Mesocricetus
    Neutralization Tests
    SARS Virus
    Severe Acute Respiratory Syndrome
    Viral Load
    Immunology and Infectious Disease
    Pediatrics
    Show allShow less
    
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    Link to Full Text
    http://dx.doi.org/10.1086/500143
    Abstract
    BACKGROUND: Immunotherapy with monoclonal antibodies (MAbs) offers safe interventions for the prevention of infection in patients after organ transplantation and for the treatment of cancers and autoimmune diseases. MAb 201 is a severe acute respiratory syndrome-associated coronavirus (SARS-CoV)-specific MAb that prevents establishment of viral replication in vitro and prevents viral replication in vivo when administered prophylactically. The efficacy of MAb 201 in the treatment of SARS was evaluated in golden Syrian hamsters, an animal model that supports SARS-CoV replication to high levels and displays severe pathological changes associated with infection, including pneumonitis and pulmonary consolidation. METHODS: Golden Syrian hamsters that were intranasally inoculated with SARS-CoV were treated with various doses of MAb 201 or an irrelevant MAb 24 h after inoculation. Two to 7 days after infection, the hamsters were killed, and their lungs were collected for evaluation of viral titers and pathological findings. RESULTS: Postexposure treatment with MAb 201 can alleviate the viral burden and associated pathological findings in a golden Syrian hamster model of SARS-CoV infection. After a hamster is treated with MAb 201, its viral burden is reduced by 102.4-103.9 50% tissue-culture infectious doses per gram of tissue, and the severity of associated pathological findings, including interstitial pneumonitis and consolidation, is also remarkably reduced. CONCLUSIONS: The demonstration of successful postexposure MAb 201 therapy in an animal model that demonstrates viral replication and associated pulmonary pathological findings suggests that MAb 201 may be useful in the arsenal of tools to combat SARS.
    Source
    J Infect Dis. 2006 Mar 1;193(5):685-92. Epub 2006 Jan 27. Link to article on publisher's site
    DOI
    10.1086/500143
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43467
    PubMed ID
    16453264
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1086/500143
    Scopus Count
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