Efficacy model for antibody-mediated pre-erythrocytic malaria vaccines
Authors
White, Michael T.Griffin, Jamie T.
Riley, Eleanor M.
Drakeley, Chris J.
Moormann, Ann M.
Sumba, Peter Odada
Kazura, James W.
Ghani, Azra C.
John, Chandy C.
Document Type
Journal ArticlePublication Date
2011-05-07Keywords
AdultAntibodies, Protozoan
Antigens, Protozoan
Erythrocytes
Female
Humans
Immunoglobulin G
Kenya
Malaria Vaccines
Malaria, Falciparum
Male
*Models, Biological
Plasmodium falciparum
Protozoan Proteins
Sporozoites
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
Antibodies to the pre-erythrocytic antigens, circumsporozoite protein (CSP), thrombospondin-related adhesive protein (TRAP) and liver-stage antigen 1, have been measured in field studies of semi-immune adults and shown to correlate with protection from Plasmodium falciparum infection. A mathematical model is formulated to estimate the probability of sporozoite infection as a function of antibody titres to multiple pre-erythrocytic antigens. The variation in antibody titres from field data was used to estimate the relationship between the probability of P. falciparum infection per infectious mosquito bite and antibody titre. Using this relationship, we predict the effect of vaccinations that boost baseline CSP or TRAP antibody titres. Assuming the estimated relationship applies to vaccine-induced antibody titres, then single-component CSP or TRAP antibody-mediated pre-erythrocytic vaccines are likely to provide partial protection from infection, with vaccine efficacy of approximately 50 per cent depending on the magnitude of the vaccine-induced boost to antibody titres. It is possible that the addition of a TRAP component to a CSP-based vaccine such as RTS,S would provide an increase in infection-blocking efficacy of approximately 25 per cent should the problem of immunological interference between antigens be overcome.Source
Proc Biol Sci. 2011 May 7;278(1710):1298-305. Epub 2010 Oct 13. Link to article on publisher's site
DOI
10.1098/rspb.2010.1697Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43487PubMed ID
20943696Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1098/rspb.2010.1697