The Ariel Project: A prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy
Authors
Van Dyke, Russell B.Korber, Bette T.
Popek, Edwina
Macken, Catherine
Widmayer, Susan M.
Bardeguez, Arlene
Hanson, I. Celine
Wiznia, Andrew
Luzuriaga, Katherine
Viscarello, Richard R.
Wolinsky, Steven M.
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
1999-02-01Keywords
Acquired Immunodeficiency SyndromeAdult
Cohort Studies
Female
Fetal Blood
*HIV-1
Humans
Infant, Newborn
*Infectious Disease Transmission, Vertical
Multivariate Analysis
Phylogeny
Placenta
Pregnancy
Prospective Studies
Risk Factors
Vagina
Immunology and Infectious Disease
Pediatrics
Metadata
Show full item recordAbstract
In a prospective cohort study, clinical and biologic factors that contribute to maternal-child transmission of human immunodeficiency virus type 1 (HIV-1) were studied. HIV-infected pregnant women and their infants were evaluated prospectively according to a standardized protocol. Of 204 evaluable women, 81% received zidovudine during their pregnancy. The infection rate among the 209 evaluable infants was 9.1%. By univariate analysis, histologic chorioamnionitis, prolonged rupture of membranes, and a history of genital warts were significantly associated with transmission. Additional factors associated with transmission that approached significance included a higher maternal virus load at delivery and the presence of cocaine in the urine. In a logistic regression model, histologic chorioamnionitis was the only independent predictor of transmission. Despite a significantly higher transmission rate at one site, no unique viral genotype was found at any site. Thus, chorioamnionitis was found to be the major risk factor for transmission among women receiving zidovudine.Source
J Infect Dis. 1999 Feb;179(2):319-28. Link to article on publisher's siteDOI
10.1086/314580Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43497PubMed ID
9878014Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/314580