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    Systemic responses of preterm newborns with presumed or documented bacteraemia

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    Authors
    Leviton, Alan
    O'Shea, T. Michael
    Bednarek, Francis J.
    Allred, Elizabeth N.
    Fichorova, Raina N.
    Dammann, Olaf
    ELGAN Study Investigators
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2012-04-01
    Keywords
    Bacteremia; Infant, Premature
    Pediatrics
    
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    Link to Full Text
    http://dx.doi.org/10.1111/j.1651-2227.2011.02527.x
    Abstract
    AIM: To compare the frequency of elevated concentrations of inflammation-related proteins in the blood of infants born before the 28th week of gestation who had documented bacteraemia and those who had presumed (antibiotic-treated but culture-negative) bacteraemia to those who had neither. METHODS: The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample. RESULTS: Newborns with presumed early (week 1) bacteraemia had elevated concentrations of only a few inflammation-related proteins, while those who had presumed late (weeks 2-4) bacteraemia did not have any elevations. In contrast, newborns who had documented early bacteraemia had a moderately strong signal, while those who had documented late bacteraemia had a stronger signal with more protein concentrations elevated on two separate occasions a week apart. CONCLUSIONS: Culture-confirmed early and late bacteraemia are accompanied/followed by systemic inflammatory responses not seen with presumed early and late bacteraemia.
    Source
    Acta Paediatr. 2012 Apr;101(4):355-9. doi: 10.1111/j.1651-2227.2011.02527.x. Epub 2011 Dec 7.
    DOI
    10.1111/j.1651-2227.2011.02527.x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43507
    PubMed ID
    22085230
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1651-2227.2011.02527.x
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