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dc.contributor.authorLeviton, Alan
dc.contributor.authorO'Shea, T. Michael
dc.contributor.authorBednarek, Francis J.
dc.contributor.authorAllred, Elizabeth N.
dc.contributor.authorFichorova, Raina N.
dc.contributor.authorDammann, Olaf
dc.contributor.authorELGAN Study Investigators
dc.date2022-08-11T08:10:12.000
dc.date.accessioned2022-08-23T16:59:05Z
dc.date.available2022-08-23T16:59:05Z
dc.date.issued2012-04-01
dc.date.submitted2012-05-30
dc.identifier.citationActa Paediatr. 2012 Apr;101(4):355-9. doi: 10.1111/j.1651-2227.2011.02527.x. Epub 2011 Dec 7.
dc.identifier.issn1651-2227
dc.identifier.doi10.1111/j.1651-2227.2011.02527.x
dc.identifier.pmid22085230
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43507
dc.description.abstractAIM: To compare the frequency of elevated concentrations of inflammation-related proteins in the blood of infants born before the 28th week of gestation who had documented bacteraemia and those who had presumed (antibiotic-treated but culture-negative) bacteraemia to those who had neither. METHODS: The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample. RESULTS: Newborns with presumed early (week 1) bacteraemia had elevated concentrations of only a few inflammation-related proteins, while those who had presumed late (weeks 2-4) bacteraemia did not have any elevations. In contrast, newborns who had documented early bacteraemia had a moderately strong signal, while those who had documented late bacteraemia had a stronger signal with more protein concentrations elevated on two separate occasions a week apart. CONCLUSIONS: Culture-confirmed early and late bacteraemia are accompanied/followed by systemic inflammatory responses not seen with presumed early and late bacteraemia.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22085230&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1111/j.1651-2227.2011.02527.x
dc.subjectBacteremia; Infant, Premature
dc.subjectPediatrics
dc.titleSystemic responses of preterm newborns with presumed or documented bacteraemia
dc.typeJournal Article
dc.source.journaltitleActa paediatrica (Oslo, Norway : 1992)
dc.source.volume101
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_neonatology/18
dc.identifier.contextkey2921568
html.description.abstract<p>AIM: To compare the frequency of elevated concentrations of inflammation-related proteins in the blood of infants born before the 28th week of gestation who had documented bacteraemia and those who had presumed (antibiotic-treated but culture-negative) bacteraemia to those who had neither.</p> <p>METHODS: The subjects of this study are the 868 infants born at 14 institutions for whom information about protein measurements on at least two of the three protocol days (days 1, 7, and 14) was available and who did not have Bell stage 3 necrotizing enterocolitis or isolated bowel perforation, which were strongly associated with bacteraemia in this sample.</p> <p>RESULTS: Newborns with presumed early (week 1) bacteraemia had elevated concentrations of only a few inflammation-related proteins, while those who had presumed late (weeks 2-4) bacteraemia did not have any elevations. In contrast, newborns who had documented early bacteraemia had a moderately strong signal, while those who had documented late bacteraemia had a stronger signal with more protein concentrations elevated on two separate occasions a week apart.</p> <p>CONCLUSIONS: Culture-confirmed early and late bacteraemia are accompanied/followed by systemic inflammatory responses not seen with presumed early and late bacteraemia.</p>
dc.identifier.submissionpathpeds_neonatology/18
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages355-9


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