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AuthorsBurns, Jane S.
Williams, Paige L.
Lee, Mary M.
Korrick, Susan A.
UMass Chan AffiliationsDepartment of Pediatrics, Division of Pediatric Endocrinology
Document TypeJournal Article
KeywordsBody mass index
Endocrinology, Diabetes, and Metabolism
Environmental Public Health
MetadataShow full item record
AbstractBACKGROUND: Childhood blood lead levels (BLL) have been associated with growth impairment. OBJECTIVES: We assessed associations of peripubertal BLL with adolescent growth and near adult height in a longitudinal cohort of Russian boys. METHODS: 481 boys were enrolled at ages 8-9years and followed annually to age 18. At enrollment, BLL was measured, and height, weight, and pubertal staging were obtained annually during 10years of follow-up. Mixed effects models were used to assess the associations of BLL with longitudinal age-adjusted World Health OrganizationZ-scores for height (HT-Z) and body mass index (BMI-Z), and annual height velocity (HV). Interactions between boys' age and BLL on growth outcomes were evaluated. RESULTS: The median (range) BLL was 3.0 (0.5-31.0) mug/dL. At age 18years, 79% of boys had achieved near adult height (HV < 1.0cm/year), and means (SD) for HT-Z and BMI-Z were 0.15 (0.92) and -0.32 (1.24). Over 10years of follow-up, after covariate adjustment, boys with higher ( > /=5mug/dL) BLL compared with lower BLL were shorter (adjusted mean difference in HT-Z=-0.43, 95% CI -0.60, -0.25, p-value < 0.001), translating to a 2.5cm lower height at age 18years. The decrement in height for boys with higher BLL was most pronounced at 12 to 15years of age (interaction p=0.03). Boys with higher BLL were leaner (adjusted mean difference in BMI-Z=-0.22, 95% CI: -0.45, 0.01, p=0.06). CONCLUSIONS: Higher peripubertal BLLs were associated with shorter height through age 18years, suggesting a persistent effect of lead on linear growth.
SourceEnviron Int. 2017 Sep;106:53-59. doi: 10.1016/j.envint.2017.05.023. Epub 2017 Jun 7. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/43584
Related ResourcesLink to Article in PubMed