Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria
UMass Chan Affiliations
MassBiologicsDepartment of Pediatrics, Division of Pediatric Immunology and Infectious Diseases
Document Type
Journal ArticlePublication Date
2017-09-21Keywords
Immunoprophylaxis and Therapy
Metadata
Show full item recordAbstract
There is a global shortage of equine-derived diphtheria anti-toxin (DAT) for diphtheria treatment. There are few existing data on serum antibody concentrations and neutralizing activity post-treatment to support development of new therapeutics. Antibody concentrations were quantified by ELISA and anti-toxin neutralizing activity by cytotoxicity assay in serum from 4 patients receiving DAT for suspected diphtheria. Using linear mixed effects modeling, estimated mean (SE) half-life was 78.2 (20.0) hours. Maximum serum neutralizing activity ranged from 28.42-38.64 AU/mL with an estimated mean AUC1-72 of 1396.7 (399.3) AU/mL*hr. These data provide a standard of comparison for development of novel anti-toxins to replace DAT.Source
Hum Vaccin Immunother. 2017 Sep 21:1-4. doi: 10.1080/21645515.2017.1362516. Link to article on publisher's siteDOI
10.1080/21645515.2017.1362516Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43604PubMed ID
28933665Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1080/21645515.2017.1362516