AuthorsGreenspan, Louise C.
Lee, Mary M.
UMass Chan AffiliationsDepartment of Pediatrics, Division of Pediatric Endocrinology
Document TypeJournal Article
endocrine disrupting compounds
Endocrinology, Diabetes, and Metabolism
Environmental Public Health
Reproductive and Urinary Physiology
MetadataShow full item record
AbstractPURPOSE OF REVIEW: The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing. RECENT FINDINGS: In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty. SUMMARY: The effects of EDCs on pubertal timing are sexually dimorphic, compound specific, and varies according to the window of exposure. These studies confirm that low-level exposures to a mix of environmental compounds may mask the effects of individual compounds and complicate our ability to translate data from animal studies to human health and to fully understand the clinical implications of environmental epidemiology studies.
SourceCurr Opin Endocrinol Diabetes Obes. 2018 Feb;25(1):49-54. doi: 10.1097/MED.0000000000000377. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/43622
Related ResourcesLink to Article in PubMed