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    Endocrine disrupters and pubertal timing

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    Authors
    Greenspan, Louise C.
    Lee, Mary M.
    UMass Chan Affiliations
    Department of Pediatrics, Division of Pediatric Endocrinology
    Document Type
    Journal Article
    Publication Date
    2018-02-01
    Keywords
    breast development
    dioxins
    endocrine disrupting compounds
    genital staging
    menarche
    pesticides
    puberty
    sexual maturation
    Endocrine System
    Endocrinology, Diabetes, and Metabolism
    Environmental Public Health
    Medical Toxicology
    Pediatrics
    Reproductive and Urinary Physiology
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    Link to Full Text
    https://doi.org/10.1097/MED.0000000000000377
    Abstract
    PURPOSE OF REVIEW: The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing. RECENT FINDINGS: In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty. SUMMARY: The effects of EDCs on pubertal timing are sexually dimorphic, compound specific, and varies according to the window of exposure. These studies confirm that low-level exposures to a mix of environmental compounds may mask the effects of individual compounds and complicate our ability to translate data from animal studies to human health and to fully understand the clinical implications of environmental epidemiology studies.
    Source
    Curr Opin Endocrinol Diabetes Obes. 2018 Feb;25(1):49-54. doi: 10.1097/MED.0000000000000377. Link to article on publisher's site
    DOI
    10.1097/MED.0000000000000377
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43622
    PubMed ID
    29135489
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1097/MED.0000000000000377
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