UMass Chan Affiliations
Department of Pediatrics, Division of Pediatric EndocrinologyDocument Type
Journal ArticlePublication Date
2018-02-01Keywords
breast developmentdioxins
endocrine disrupting compounds
genital staging
menarche
pesticides
puberty
sexual maturation
Endocrine System
Endocrinology, Diabetes, and Metabolism
Environmental Public Health
Medical Toxicology
Pediatrics
Reproductive and Urinary Physiology
Metadata
Show full item recordAbstract
PURPOSE OF REVIEW: The current review summarizes recent epidemiologic data demonstrating the effects of endocrine disrupting compounds (EDCs) on the timing of puberty and highlights the complexity of understanding the interplay of environmental and genetic factors on pubertal timing. RECENT FINDINGS: In girls, there have been mixed results, with some exposures being associated with earlier timing of puberty, and some with later puberty. In boys, prepubertal exposures to nondioxin-like polychlorinated biphenyls accelerate puberty, whereas levels of insecticides, dioxin-like compounds, organochlorine pesticides, and lead delay puberty. SUMMARY: The effects of EDCs on pubertal timing are sexually dimorphic, compound specific, and varies according to the window of exposure. These studies confirm that low-level exposures to a mix of environmental compounds may mask the effects of individual compounds and complicate our ability to translate data from animal studies to human health and to fully understand the clinical implications of environmental epidemiology studies.Source
Curr Opin Endocrinol Diabetes Obes. 2018 Feb;25(1):49-54. doi: 10.1097/MED.0000000000000377. Link to article on publisher's siteDOI
10.1097/MED.0000000000000377Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43622PubMed ID
29135489Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1097/MED.0000000000000377