Peripubertal serum dioxin concentrations and subsequent sperm methylome profiles of young Russian adults
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UMass Chan Affiliations
Department of Psychiatry, Brudnick Neuropsychiatric Research InstituteDepartment of Pediatrics, Division of Endocrinology
Document Type
Journal ArticlePublication Date
2018-03-14Keywords
DNA methylationEndocrine disrupting chemicals
Environmental effects
Peripuberty
Russian Children’s Study
Sperm methylome
Susceptible window of germ cell development
Whole genome bisulfite sequencing
Environmental Public Health
Medical Toxicology
Pediatrics
Reproductive and Urinary Physiology
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Show full item recordAbstract
BACKGROUND: The association of exposure to endocrine disrupting chemicals in the peripubertal period with subsequent sperm DNA methylation is unknown. OBJECTIVE: We examined the association of peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) concentrations with whole-genome bisulfite sequencing (WGBS) of sperm collected in young adulthood. METHODS: The Russian Children's Study is a prospective cohort of 516 boys who were enrolled at 8-9 years of age and provided semen samples at 18-19 years of age. WGBS of sperm was conducted to identify differentially methylated regions (DMR) between highest (n=4) and lowest (n=4) peripubertal TCDD groups. RESULTS: We found 52 DMRs that distinguished lowest and highest peripubertal serum TCDD concentrations. One of the top scoring networks, "Cellular Assembly and Organization, Cellular Function and Maintenance, Carbohydrate Metabolism", identified estrogen receptor alpha as its central regulator. CONCLUSION: Findings from our limited sample size suggest that peripubertal environmental exposures are associated with sperm DNA methylation in young adults.Source
Reprod Toxicol. 2018 Mar 14;78:40-49. doi: 10.1016/j.reprotox.2018.03.007. Link to article on publisher's site
DOI
10.1016/j.reprotox.2018.03.007Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43638PubMed ID
29550351Notes
Full list of authors omitted for brevity. For full list see article.
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10.1016/j.reprotox.2018.03.007