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    The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection

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    journal.pcbi.1002729_1_.pdf
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    Authors
    Pinkevych, Mykola
    Petravic, Janka
    Chelimo, Kiprotich
    Kazura, James W.
    Moormann, Ann M.
    Davenport, Miles P.
    UMass Chan Affiliations
    Department of Pediatrics
    Department of Quantitative Health Sciences
    Document Type
    Journal Article
    Publication Date
    2012-10-18
    Keywords
    Malaria, Falciparum
    Plasmodium falciparum
    Immunity, Innate
    Immunology and Infectious Disease
    Parasitic Diseases
    
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    Abstract
    Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The relative contribution of immunity against various stages of the parasite life cycle that results in controlling infection and limiting disease is not well understood. Here we analyse the dynamics of Plasmodium falciparum malaria infection after treatment in a cohort of 197 healthy study participants of different ages in order to model naturally acquired immunity. We find that both delayed time-to-infection and reductions in asymptomatic parasitaemias in older age groups can be explained by immunity that reduces the growth of blood stage as opposed to liver stage parasites. We found that this mechanism would require at least two components - a rapidly acting strain-specific component, as well as a slowly acquired cross-reactive or general immunity to all strains. Analysis and modelling of malaria infection dynamics and naturally acquired immunity with age provides important insights into what mechanisms of immune control may be harnessed by malaria vaccine strategists.
    Source
    Pinkevych M, Petravic J, Chelimo K, Kazura JW, Moormann AM, et al. (2012) The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection. PLoS Comput Biol 8(10): e1002729. doi:10.1371/journal.pcbi.1002729. Link to article on publisher's site
    DOI
    10.1371/journal.pcbi.1002729
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43657
    PubMed ID
    23093922
    Related Resources
    Link to Article in PubMed
    Rights
    Copyright: © Pinkevych et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
    ae974a485f413a2113503eed53cd6c53
    10.1371/journal.pcbi.1002729
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