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dc.contributor.authorPinkevych, Mykola
dc.contributor.authorPetravic, Janka
dc.contributor.authorChelimo, Kiprotich
dc.contributor.authorKazura, James W.
dc.contributor.authorMoormann, Ann M.
dc.contributor.authorDavenport, Miles P.
dc.date2022-08-11T08:10:13.000
dc.date.accessioned2022-08-23T16:59:45Z
dc.date.available2022-08-23T16:59:45Z
dc.date.issued2012-10-18
dc.date.submitted2012-12-10
dc.identifier.citationPinkevych M, Petravic J, Chelimo K, Kazura JW, Moormann AM, et al. (2012) The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection. PLoS Comput Biol 8(10): e1002729. doi:10.1371/journal.pcbi.1002729. <a href="http://dx.doi.org/10.1371/journal.pcbi.1002729" target="_blank">Link to article on publisher's site</a>
dc.identifier.issn1553-734X (Linking)
dc.identifier.doi10.1371/journal.pcbi.1002729
dc.identifier.pmid23093922
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43657
dc.description.abstractSevere malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The relative contribution of immunity against various stages of the parasite life cycle that results in controlling infection and limiting disease is not well understood. Here we analyse the dynamics of Plasmodium falciparum malaria infection after treatment in a cohort of 197 healthy study participants of different ages in order to model naturally acquired immunity. We find that both delayed time-to-infection and reductions in asymptomatic parasitaemias in older age groups can be explained by immunity that reduces the growth of blood stage as opposed to liver stage parasites. We found that this mechanism would require at least two components - a rapidly acting strain-specific component, as well as a slowly acquired cross-reactive or general immunity to all strains. Analysis and modelling of malaria infection dynamics and naturally acquired immunity with age provides important insights into what mechanisms of immune control may be harnessed by malaria vaccine strategists.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=23093922&dopt=Abstract">Link to Article in PubMed</a>
dc.rightsCopyright: © Pinkevych et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.subjectMalaria, Falciparum
dc.subjectPlasmodium falciparum
dc.subjectImmunity, Innate
dc.subjectImmunology and Infectious Disease
dc.subjectParasitic Diseases
dc.titleThe Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection
dc.typeArticle
dc.source.journaltitlePLoS computational biology
dc.source.volume8
dc.source.issue10
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1022&amp;context=peds_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_pp/23
dc.identifier.contextkey3523816
refterms.dateFOA2022-08-23T16:59:45Z
html.description.abstract<p>Severe malaria occurs predominantly in young children and immunity to clinical disease is associated with cumulative exposure in holoendemic settings. The relative contribution of immunity against various stages of the parasite life cycle that results in controlling infection and limiting disease is not well understood. Here we analyse the dynamics of Plasmodium falciparum malaria infection after treatment in a cohort of 197 healthy study participants of different ages in order to model naturally acquired immunity. We find that both delayed time-to-infection and reductions in asymptomatic parasitaemias in older age groups can be explained by immunity that reduces the growth of blood stage as opposed to liver stage parasites. We found that this mechanism would require at least two components - a rapidly acting strain-specific component, as well as a slowly acquired cross-reactive or general immunity to all strains. Analysis and modelling of malaria infection dynamics and naturally acquired immunity with age provides important insights into what mechanisms of immune control may be harnessed by malaria vaccine strategists.</p>
dc.identifier.submissionpathpeds_pp/23
dc.contributor.departmentDepartment of Pediatrics
dc.contributor.departmentDepartment of Quantitative Health Sciences
dc.source.pagese1002729


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