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The optimization of home oxygen weaning in premature infants trial: Design, rationale, methods, and lessons learned
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Authors
Procaskey, AlexanderWhite, Heather
Simoneau, Tregony
Traeger, Nadav
Lahiri, Thomas
Jawdeh, Elie G. Abu
Kremer, Ted M.
Sheils, Catherine
Meyer, Kathleen
Rosenkrantz, Ted
Krishnan, Sankaran
Hartman, Tyler
Feldman, Henry
Rhein, Lawrence M.
UMass Chan Affiliations
Department of Pediatrics, Division of Pediatric PulmonologyDepartment of Pediatrics, Division of Pediatric Neonatology
Document Type
Journal ArticlePublication Date
2018-12-01
Metadata
Show full item recordAbstract
Improved survival among preterm infants has led to an increase in diagnosis of chronic lung disease and infants discharged home from the NICU on supplemental oxygen. Despite this increased prevalence, no clearly defined guidelines for the management of home oxygen therapy (HOT) exist. This lack of consensus leads to significant variability in the duration of home oxygen therapy and a general paucity of evidence-based practice. Our team has identified recorded home oxygen therapy (RHO) as a potential new resource to guide clinical decision making in the outpatient pulmonology clinic. By recording extended O2 saturation data during the weaning process, RHO has the potential to save cost and improve the processes of HOT management. Our team is currently supporting a prospective, multi-center, randomized, controlled trial of RHO guided HOT weaning with the aims of determining effect upon duration of HOT, perceived parent quality of life and effect upon growth and respiratory outcomes. We plan to randomize 196 infants into one of two study arms evaluating standard HOT management versus RHO guided oxygen weaning. Our primary outcomes are total HOT duration and parental quality of life. This trial represents an unprecedented opportunity to test a novel home monitoring intervention for weaning within a vulnerable yet quickly growing population. If effective, the use of RHO may provide clinicians a tool for safe weaning.Source
Contemp Clin Trials. 2018 Dec;75:72-77. doi: 10.1016/j.cct.2018.08.001. Epub 2018 Aug 11. Link to article on publisher's site
DOI
10.1016/j.cct.2018.08.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43658PubMed ID
30107239Related Resources
ae974a485f413a2113503eed53cd6c53
10.1016/j.cct.2018.08.001