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    The optimization of home oxygen weaning in premature infants trial: Design, rationale, methods, and lessons learned

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    Authors
    Procaskey, Alexander
    White, Heather
    Simoneau, Tregony
    Traeger, Nadav
    Lahiri, Thomas
    Jawdeh, Elie G. Abu
    Kremer, Ted M.
    Sheils, Catherine
    Meyer, Kathleen
    Rosenkrantz, Ted
    Krishnan, Sankaran
    Hartman, Tyler
    Feldman, Henry
    Rhein, Lawrence M.
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    UMass Chan Affiliations
    Department of Pediatrics, Division of Pediatric Pulmonology
    Department of Pediatrics, Division of Pediatric Neonatology
    Document Type
    Journal Article
    Publication Date
    2018-12-01
    Keywords
    Health Services Administration
    Pediatrics
    Respiratory Tract Diseases
    Therapeutics
    
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    Link to Full Text
    https://doi.org/10.1016/j.cct.2018.08.001
    Abstract
    Improved survival among preterm infants has led to an increase in diagnosis of chronic lung disease and infants discharged home from the NICU on supplemental oxygen. Despite this increased prevalence, no clearly defined guidelines for the management of home oxygen therapy (HOT) exist. This lack of consensus leads to significant variability in the duration of home oxygen therapy and a general paucity of evidence-based practice. Our team has identified recorded home oxygen therapy (RHO) as a potential new resource to guide clinical decision making in the outpatient pulmonology clinic. By recording extended O2 saturation data during the weaning process, RHO has the potential to save cost and improve the processes of HOT management. Our team is currently supporting a prospective, multi-center, randomized, controlled trial of RHO guided HOT weaning with the aims of determining effect upon duration of HOT, perceived parent quality of life and effect upon growth and respiratory outcomes. We plan to randomize 196 infants into one of two study arms evaluating standard HOT management versus RHO guided oxygen weaning. Our primary outcomes are total HOT duration and parental quality of life. This trial represents an unprecedented opportunity to test a novel home monitoring intervention for weaning within a vulnerable yet quickly growing population. If effective, the use of RHO may provide clinicians a tool for safe weaning.
    Source

    Contemp Clin Trials. 2018 Dec;75:72-77. doi: 10.1016/j.cct.2018.08.001. Epub 2018 Aug 11. Link to article on publisher's site

    DOI
    10.1016/j.cct.2018.08.001
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43658
    PubMed ID
    30107239
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cct.2018.08.001
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