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dc.contributor.authorHardy, Olga T.
dc.contributor.authorKim, Albert
dc.contributor.authorCiccarelli, Carol A.
dc.contributor.authorHayman, Laura L.
dc.contributor.authorWiecha, Jean
dc.date2022-08-11T08:10:13.000
dc.date.accessioned2022-08-23T16:59:46Z
dc.date.available2022-08-23T16:59:46Z
dc.date.issued2013-02-01
dc.date.submitted2012-12-10
dc.identifier.citation<p>Hardy, O. T., Kim, A., Ciccarelli, C., Hayman, L. L. and Wiecha, J. (2013), Increased Toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents. Pediatric Obesity, 8: e19–e23. doi: 10.1111/j.2047-6310.2012.00098.x <a href="http://dx.doi.org/10.1111/j.2047-6310.2012.00098.x">Link to article on publisher's site</a></p>
dc.identifier.issn2047-6302 (Linking)
dc.identifier.doi10.1111/j.2047-6310.2012.00098.x
dc.identifier.pmid22991262
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43663
dc.description.abstractBACKGROUND: Metabolic syndrome (MetSyn) is diagnosed frequently in some but not all overweight adolescents. Chronic inflammation, as seen in obesity, is strongly associated with MetSyn. OBJECTIVES: The aim of this pilot study was to assess the correlation between activation of the innate immune system and MetSyn, independent of body mass index (BMI), in a young population. METHODS: We quantitatively measured both systemic pro-inflammatory cytokines and gene expression of Toll-like receptors (TLRs) and downstream cytokines in circulating monocytes obtained from nine adolescents with metabolic syndrome (Overwt-MetSyn) and eight BMI-matched controls (Overwt-Healthy). RESULTS: The Overwt-MetSyn group demonstrated a significant elevation in expression of TLR2, TLR4, tumour necrosis factor-a (TNF a) and interleukin-6 (IL6) in peripheral monocytes, and increased circulating levels of TNF a and IL6 when compared with the Overwt-Healthy group. TLR2 (r = 0.78, P < 0.001), TLR4 (r = 0.57, P < 0.01) and TNF a (r = 0.61, P < 0.01) gene expression positively correlated with serum levels of TNF a. CONCLUSIONS: Our study suggests that activation of the innate immune pathway via TLRs may be partially responsible for the increased systemic inflammation seen in adolescents with MetSyn. the Study of Obesity.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22991262&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546604/
dc.subjectMetabolic Syndrome X
dc.subjectAdolescent
dc.subjectImmunity, Innate
dc.subjectToll-Like Receptors
dc.subjectUMCCTS funding
dc.subjectImmunity
dc.subjectNutritional and Metabolic Diseases
dc.subjectPediatrics
dc.titleIncreased Toll-like receptor (TLR) mRNA expression in monocytes is a feature of metabolic syndrome in adolescents
dc.typeJournal Article
dc.source.journaltitlePediatric obesity
dc.source.volume8
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_pp/24
dc.identifier.contextkey3523817
html.description.abstract<p>BACKGROUND: Metabolic syndrome (MetSyn) is diagnosed frequently in some but not all overweight adolescents. Chronic inflammation, as seen in obesity, is strongly associated with MetSyn.</p> <p>OBJECTIVES: The aim of this pilot study was to assess the correlation between activation of the innate immune system and MetSyn, independent of body mass index (BMI), in a young population.</p> <p>METHODS: We quantitatively measured both systemic pro-inflammatory cytokines and gene expression of Toll-like receptors (TLRs) and downstream cytokines in circulating monocytes obtained from nine adolescents with metabolic syndrome (Overwt-MetSyn) and eight BMI-matched controls (Overwt-Healthy).</p> <p>RESULTS: The Overwt-MetSyn group demonstrated a significant elevation in expression of TLR2, TLR4, tumour necrosis factor-a (TNF a) and interleukin-6 (IL6) in peripheral monocytes, and increased circulating levels of TNF a and IL6 when compared with the Overwt-Healthy group. TLR2 (r = 0.78, P < 0.001), TLR4 (r = 0.57, P < 0.01) and TNF a (r = 0.61, P < 0.01) gene expression positively correlated with serum levels of TNF a.</p> <p>CONCLUSIONS: Our study suggests that activation of the innate immune pathway via TLRs may be partially responsible for the increased systemic inflammation seen in adolescents with MetSyn. the Study of Obesity.</p>
dc.identifier.submissionpathpeds_pp/24
dc.contributor.departmentDepartment of Pediatrics
dc.source.pagese19-e23


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