Show simple item record

dc.contributor.authorZantek, Nicole D.
dc.contributor.authorParker, Robert I.
dc.contributor.authorvan de Watering, Leo M.
dc.contributor.authorJosephson, Cassandra D.
dc.contributor.authorBateman, Scot T.
dc.contributor.authorValentine, Stacey L.
dc.contributor.authorDelaney, Meghan
dc.date2022-08-11T08:10:13.000
dc.date.accessioned2022-08-23T16:59:49Z
dc.date.available2022-08-23T16:59:49Z
dc.date.issued2018-09-01
dc.date.submitted2018-12-21
dc.identifier.citation<p>Pediatr Crit Care Med. 2018 Sep;19(9S Suppl 1):S163-S169. doi: 10.1097/PCC.0000000000001625. <a href="https://doi.org/10.1097/PCC.0000000000001625">Link to article on publisher's site</a></p>
dc.identifier.issn1529-7535 (Linking)
dc.identifier.doi10.1097/PCC.0000000000001625
dc.identifier.pmid30161072
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43673
dc.description.abstractOBJECTIVES: To present the recommendations and supporting literature for selection and processing of RBC products in critically ill children developed by the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. DESIGN: Consensus conference series of international, multidisciplinary experts in RBC transfusion management of critically ill children METHODS:: The panel of 38 experts developed evidence-based, and when evidence was lacking, expert-based clinical recommendations as well as research priorities for RBC transfusions in critically ill children. The RBC processing subgroup included five experts. Electronic searches were conducted using PubMed, EMBASE, and Cochrane Library databases from 1980 to May 2017. Agreement was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. RESULTS: Five recommendations reached agreement ( > 80%). Irradiated cellular products are recommended for children at risk of transfusion-associated graft versus host disease due to severe congenital or acquired causes of immune deficiency or when the blood donor is a blood relative. Washed cellular blood components and avoidance of other plasma-containing products are recommended for critically ill children with history of severe allergic reactions or anaphylaxis to blood transfusions, although patient factors appear to be important in the pathogenesis of reactions. For children with history of severe allergic transfusion reactions, evaluation for allergic stigmata prior to transfusion is recommended. In children with severe immunoglobulin A deficiency with evidence of antiimmunoglobulin A antibodies and/or a history of a severe transfusion reaction, immunoglobulin A-deficient blood components obtained either from an immunoglobulin A-deficient donor and/or washed cellular components is recommended. CONCLUSIONS: The Transfusion and Anemia Expertise Initiative consensus conference developed recommendations for selection and processing of RBC units for critically ill children. Recommendations in this area are largely based on pediatric and adult case report data.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=30161072&dopt=Abstract">Link to Article in PubMed</a></p>
dc.relation.urlhttps://doi.org/10.1097/PCC.0000000000001625
dc.subjectallergic reaction
dc.subjectconsensus development conference
dc.subjectcritical illness
dc.subjectgraft versus host disease
dc.subjectimmunoglobulin A deficiency
dc.subjectirradiation
dc.subjectCritical Care
dc.subjectHealth Services Administration
dc.subjectHemic and Lymphatic Diseases
dc.subjectPediatrics
dc.subjectTherapeutics
dc.titleRecommendations on Selection and Processing of RBC Components for Pediatric Patients From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative
dc.typeArticle
dc.source.journaltitlePediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
dc.source.volume19
dc.source.issue9S Suppl 1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/peds_pp/249
dc.identifier.contextkey13525471
html.description.abstract<p>OBJECTIVES: To present the recommendations and supporting literature for selection and processing of RBC products in critically ill children developed by the Pediatric Critical Care Transfusion and Anemia Expertise Initiative.</p> <p>DESIGN: Consensus conference series of international, multidisciplinary experts in RBC transfusion management of critically ill children</p> <p>METHODS:: The panel of 38 experts developed evidence-based, and when evidence was lacking, expert-based clinical recommendations as well as research priorities for RBC transfusions in critically ill children. The RBC processing subgroup included five experts. Electronic searches were conducted using PubMed, EMBASE, and Cochrane Library databases from 1980 to May 2017. Agreement was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method.</p> <p>RESULTS: Five recommendations reached agreement ( > 80%). Irradiated cellular products are recommended for children at risk of transfusion-associated graft versus host disease due to severe congenital or acquired causes of immune deficiency or when the blood donor is a blood relative. Washed cellular blood components and avoidance of other plasma-containing products are recommended for critically ill children with history of severe allergic reactions or anaphylaxis to blood transfusions, although patient factors appear to be important in the pathogenesis of reactions. For children with history of severe allergic transfusion reactions, evaluation for allergic stigmata prior to transfusion is recommended. In children with severe immunoglobulin A deficiency with evidence of antiimmunoglobulin A antibodies and/or a history of a severe transfusion reaction, immunoglobulin A-deficient blood components obtained either from an immunoglobulin A-deficient donor and/or washed cellular components is recommended.</p> <p>CONCLUSIONS: The Transfusion and Anemia Expertise Initiative consensus conference developed recommendations for selection and processing of RBC units for critically ill children. Recommendations in this area are largely based on pediatric and adult case report data.</p>
dc.identifier.submissionpathpeds_pp/249
dc.contributor.departmentDivision of Pediatric Critical Care, Department of Pediatrics
dc.source.pagesS163-S169


This item appears in the following Collection(s)

Show simple item record