Excipients in Oral Antihistamines Can Perpetuate Allergic Contact Dermatitis
Authors
Tocci, Elizabeth M.Robinson, Amanda
Belazarian, Leah
Foley, Elizabeth
Wiss, Karen
Silvestri, Dianne L.
Document Type
Case ReportPublication Date
2015-09-04Keywords
Chemical Actions and UsesDermatology
Immune System Diseases
Organic Chemicals
Pediatrics
Pharmaceutical Preparations
Skin and Connective Tissue Diseases
Therapeutics
Metadata
Show full item recordAbstract
Propylene glycol is a well-documented causative agent of allergic contact dermatitis (ACD). It is also reported to cause systemic dermatitis after ingestion of foods or medicines containing it and after intravenous injection of a medicine with propylene glycol in its base. We describe two adolescents with sensitivity to propylene glycol confirmed by patch testing whose dermatitis improved dramatically after cessation of oral antihistamines containing propylene glycol. We report these cases to alert providers to the potential for worsening of ACD due to systemic exposure to propylene glycol in patients with a cutaneous sensitivity to the allergen.Source
Pediatr Dermatol. 2015 Nov-Dec;32(6):e242-4. doi: 10.1111/pde.12668. Epub 2015 Sep 4. Link to article on publisher's site
DOI
10.1111/pde.12668Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43749PubMed ID
26381657Related Resources
ae974a485f413a2113503eed53cd6c53
10.1111/pde.12668