Antibodies to Toxin B Are Protective Against Clostridium difficile Infection Recurrence
Authors
Gupta, Swati B.Mehta, Vinay
Dubberke, Erik R.
Zhao, Xuemei
Dorr, Mary Beth
Guris, Dalya
Molrine, Deborah C.
Leney, Mark
Miller, Mark
Dupin, Marilyne
Mast, T. Christopher
UMass Chan Affiliations
Department of MedicineMassBiologics
Department of Pediatrics, Division of Immunology/Infectious Disease
Document Type
Journal ArticlePublication Date
2016-09-15Keywords
antibodiesepidemiology
risk factors
serology
toxin A
Bacterial Infections and Mycoses
Immunology and Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
BACKGROUND: Although newer studies have evaluated risk factors for recurrent Clostridium difficile infection (CDI), the vast majority did not measure important biomarkers such as endogenous anti-toxin A and anti-toxin B antibody levels. METHODS: Data from the placebo group of a phase 2 trial testing monoclonal antibodies to C. difficile toxins A and B for preventing CDI recurrence (rCDI) were analyzed to assess risk factors associated with rCDI. Patients with symptomatic CDI taking metronidazole or vancomycin were enrolled. The primary outcome was rCDI within 84 days of treatment start. Univariate and multivariate logistic regression was used to examine associations between potential risk factors and rCDI. At baseline, demographic and clinical characteristics were recorded; endogenous antibody levels were assessed using 2 enzyme-linked immunosorbent assays. RESULTS: A predictor of recurrence was age > /=65 years, and an antibody-mediated immune response to toxin B appears to be protective against rCDI. CONCLUSIONS: Our findings demonstrate the importance of clinical as well as immunological risk factors in rCDI and provide more robust evidence for the protective effects of antibody to toxin B in the prevention of rCDI. CLINICAL TRIALS REGISTRATION: NCT00350298.Source
Clin Infect Dis. 2016 Sep 15;63(6):730-4. doi: 10.1093/cid/ciw364. Epub 2016 Jun 30. Link to article on publisher's siteDOI
10.1093/cid/ciw364Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43782PubMed ID
27365387Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1093/cid/ciw364