Cystic fibrosis heterozygotes do not have increased platelet activation
Michelson, Alan D.
Frelinger, Andrew L. III
Linden, Matthew Dean
Fox, Marsha L.
Barnard, Marc R.
O'Sullivan, Brian P.
UMass Chan AffiliationsDepartment of Pediatrics
Document TypeJournal Article
Cystic Fibrosis Transmembrane Conductance Regulator
Cystic fibrosis carriers
Allergy and Immunology
Amino Acids, Peptides, and Proteins
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Digestive System Diseases
Respiratory Tract Diseases
MetadataShow full item record
AbstractINTRODUCTION: We have previously demonstrated platelet hyperreactivity in cystic fibrosis (CF) patients. Carriers of one CF mutation (heterozygotes) have been shown to have abnormalities related to the presence of only one-half the normal amount of CF transmembrane conductance regulator protein. Platelet hyperreactivity in CF heterozygotes would be an important cardiovascular risk factor, since approximately 1 in 25 Caucasians is a CF carrier. MATERIALS AND METHODS: We used highly sensitive assays of platelet activation to assess the difference between 16 CF heterozygotes and 16 age- and sex-matched healthy controls without CF mutations. RESULTS: We found no difference in platelet activation between CF heterozygotes and controls. CONCLUSIONS: The 50% reduction in the CF transmembrane conductance regulator protein in heterozygotes is insufficient to cause platelet activation.
Thromb Res. 2007;121(2):159-62. Epub 2007 May 29. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/43800
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