Cystic fibrosis heterozygotes do not have increased platelet activation
Name:
Publisher version
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
2007-05-29Keywords
AdultCase-Control Studies
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
Female
*Heterozygote
Humans
Male
Middle Aged
Platelet ActivationPlateletsCystic fibrosisFlow cytometryCystic fibrosis carriersPlatelet functionAllergy and ImmunologyAmino Acids, Peptides, and ProteinsCongenital, Hereditary, and Neonatal Diseases and AbnormalitiesDigestive System DiseasesGenetic PhenomenaHematologyInvestigative TechniquesPediatricsRespiratory Tract Diseases
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INTRODUCTION: We have previously demonstrated platelet hyperreactivity in cystic fibrosis (CF) patients. Carriers of one CF mutation (heterozygotes) have been shown to have abnormalities related to the presence of only one-half the normal amount of CF transmembrane conductance regulator protein. Platelet hyperreactivity in CF heterozygotes would be an important cardiovascular risk factor, since approximately 1 in 25 Caucasians is a CF carrier. MATERIALS AND METHODS: We used highly sensitive assays of platelet activation to assess the difference between 16 CF heterozygotes and 16 age- and sex-matched healthy controls without CF mutations. RESULTS: We found no difference in platelet activation between CF heterozygotes and controls. CONCLUSIONS: The 50% reduction in the CF transmembrane conductance regulator protein in heterozygotes is insufficient to cause platelet activation.Source
Thromb Res. 2007;121(2):159-62. Epub 2007 May 29. Link to article on publisher's site
DOI
10.1016/j.thromres.2007.04.004Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43800PubMed ID
17532368Related Resources
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