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dc.contributor.authorWang, Yong-Xu
dc.contributor.authorZhang, Chung-Li
dc.contributor.authorYu, Ruth T.
dc.contributor.authorCho, Helen K.
dc.contributor.authorNelson, Michael C.
dc.contributor.authorBayuga-Ocampo, Corinne R.
dc.contributor.authorHam, Jungyeob
dc.contributor.authorKang, Heonjoong
dc.contributor.authorEvans, Ronald M.
dc.date2022-08-11T08:10:15.000
dc.date.accessioned2022-08-23T17:01:04Z
dc.date.available2022-08-23T17:01:04Z
dc.date.issued2004-08-26
dc.date.submitted2011-04-19
dc.identifier.citationPLoS Biol. 2004 Oct;2(10):e294. Epub 2004 Aug 24. <a href="http://dx.doi.org/10.1371/journal.pbio.0020294">Link to article on publisher's site</a>
dc.identifier.issn1544-9173 (Linking)
dc.identifier.doi10.1371/journal.pbio.0020294
dc.identifier.pmid15328533
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43927
dc.description.abstractEndurance exercise training can promote an adaptive muscle fiber transformation and an increase of mitochondrial biogenesis by triggering scripted changes in gene expression. However, no transcription factor has yet been identified that can direct this process. We describe the engineering of a mouse capable of continuous running of up to twice the distance of a wild-type littermate. This was achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor delta (PPARdelta) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers. Treatment of wild-type mice with PPARdelta agonist elicits a similar type I fiber gene expression profile in muscle. Moreover, these genetically generated fibers confer resistance to obesity with improved metabolic profiles, even in the absence of exercise. These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=15328533&dopt=Abstract">Link to Article in PubMed</a>
dc.subjectAnimals
dc.subjectDNA, Mitochondrial
dc.subjectExpressed Sequence Tags
dc.subjectGene Expression Regulation
dc.subjectLigands
dc.subjectLipid Metabolism
dc.subjectMice
dc.subjectMice, Transgenic
dc.subjectMitochondria
dc.subjectModels, Statistical
dc.subjectMuscle Fibers, Skeletal
dc.subjectObesity
dc.subjectOxygen
dc.subjectPPAR delta
dc.subject*Physical Conditioning, Animal
dc.subjectPhysical Exertion
dc.subjectProtein Structure, Tertiary
dc.subjectRunning
dc.subjectSignal Transduction
dc.subjectTime Factors
dc.subjectGenetics and Genomics
dc.titleRegulation of muscle fiber type and running endurance by PPARdelta
dc.typeJournal Article
dc.source.journaltitlePLoS biology
dc.source.volume2
dc.source.issue10
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1138&amp;context=pgfe_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/pgfe_pp/138
dc.identifier.contextkey1946793
refterms.dateFOA2022-08-23T17:01:04Z
html.description.abstract<p>Endurance exercise training can promote an adaptive muscle fiber transformation and an increase of mitochondrial biogenesis by triggering scripted changes in gene expression. However, no transcription factor has yet been identified that can direct this process. We describe the engineering of a mouse capable of continuous running of up to twice the distance of a wild-type littermate. This was achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor delta (PPARdelta) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers. Treatment of wild-type mice with PPARdelta agonist elicits a similar type I fiber gene expression profile in muscle. Moreover, these genetically generated fibers confer resistance to obesity with improved metabolic profiles, even in the absence of exercise. These results demonstrate that complex physiologic properties such as fatigue, endurance, and running capacity can be molecularly analyzed and manipulated.</p>
dc.identifier.submissionpathpgfe_pp/138
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentProgram in Gene Function and Expression
dc.source.pagese294


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