Document Type
Journal ArticlePublication Date
2004-04-02Keywords
AdipocytesAppetite
Diabetes Mellitus, Type 2
Energy Metabolism
Glucose
Homeostasis
Humans
Lipids
Obesity
Receptor, Insulin
Receptors, Cytoplasmic and Nuclear
Signal Transduction
Transcription Factors
Genetics and Genomics
Metadata
Show full item recordAbstract
Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their intimate link. The three 'lipid-sensing' peroxisome proliferator-activated receptors (PPAR-alpha, PPAR-gamma and PPAR-delta) exemplify this connection, regulating diverse aspects of lipid and glucose homeostasis, and serving as bona fide therapeutic targets. With molecular underpinnings now in place, new pharmacologic approaches to metabolic disease and new questions are emerging.Source
Nat Med. 2004 Apr;10(4):355-61. Link to article on publisher's siteDOI
10.1038/nm1025Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43932PubMed ID
15057233Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1038/nm1025