C/EBPalpha in leukemogenesis: a matter of being in the right place with the right signals
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Authors
Castilla, Lucio H.UMass Chan Affiliations
Program in Gene Function and ExpressionDocument Type
Journal ArticlePublication Date
2008-04-09Keywords
AnimalsCCAAT-Enhancer-Binding Protein-alpha
Gene Expression Profiling
Leukemia, Myelomonocytic, Acute
Mice
Mutant Proteins
Myeloid Progenitor Cells
Neoplastic Stem Cells
Protein Isoforms
Cancer Biology
Genetics and Genomics
Metadata
Show full item recordAbstract
Leukemia-initiating cells can originate from hematopoietic progenitor cells that have acquired self-renewal capacity upon transformation with leukemic fusion genes. In this issue of Cancer Cell, Kirstetter and colleagues describe a mouse model for the frequent CEBPA mutations in human acute myeloid leukemia that result in the synthesis of only the 30kDa isoform, but not the 42kDa isoform of C/EBPalpha. This mutation uncouples C/EBPalpha's roles in myeloid differentiation and proliferation control. Furthermore, this mutation activates self-renewal in committed myeloid progenitor cells and induces myeloid malignancy with complete penetrance that is sustained by leukemia-initiating cells with a committed myeloid molecular signature.Source
Cancer Cell. 2008 Apr;13(4):289-91. Link to article on publisher's siteDOI
10.1016/j.ccr.2008.03.009Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43937PubMed ID
18394549Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.ccr.2008.03.009