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    Chromatin globules: a common motif of higher order chromosome structure

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    Authors
    Sanyal, Amartya
    Bau, Davide
    Marti-Renom, Marc A.
    Dekker, Job
    UMass Chan Affiliations
    Department of Biochemistry and Molecular Pharmacology
    Program in Gene Function and Expression
    Document Type
    Journal Article
    Publication Date
    2011-06-15
    Keywords
    Chromatin
    Chromosome Structures
    Protein Conformation
    Genetics and Genomics
    
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109114/pdf/nihms290515.pdf
    Abstract
    Recent technological advances in the field of chromosome conformation capture are facilitating tremendous progress in the ability to map the three-dimensional (3D) organization of chromosomes at a resolution of several Kb and at the scale of complete genomes. Here we review progress in analyzing chromosome organization in human cells by building 3D models of chromatin based on comprehensive chromatin interaction datasets. We describe recent experiments that suggest that long-range interactions between active functional elements are sufficient to drive folding of local chromatin domains into compact globular states. We propose that chromatin globules are commonly formed along chromosomes, in a cell type specific pattern, as a result of frequent long-range interactions among active genes and nearby regulatory elements. Further, we speculate that increasingly longer range interactions can drive aggregation of groups of globular domains. This process would yield a compartmentalized chromosome conformation, consistent with recent observations obtained with genome-wide chromatin interaction mapping.
    Source
    Curr Opin Cell Biol. 2011 Jun;23(3):325-31. Epub 2011 Apr 12. Link to article on publisher's site
    DOI
    10.1016/j.ceb.2011.03.009
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43941
    PubMed ID
    21489772
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ceb.2011.03.009
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