Authors
Meyers, Richard M.ENCODE Project Consortium
Dekker, Job
Lajoie, Bryan R.
Sanyal, Amartya
Weng, Zhiping
Whitfield, Troy W.
Wang, Jie
UMass Chan Affiliations
Program in Bioinformatics and Integrative BiologyProgram in Gene Function and Expression
Document Type
Journal ArticlePublication Date
2011-04-19
Metadata
Show full item recordAbstract
The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.Source
The ENCODE Project Consortium (2011) A User's Guide to the Encyclopedia of DNA Elements (ENCODE). PLoS Biol 9(4): e1001046. doi:10.1371/journal.pbio.1001046. Link to article on publisher's siteDOI
10.1371/journal.pbio.1001046Permanent Link to this Item
http://hdl.handle.net/20.500.14038/43949PubMed ID
21526222Notes
Job Dekker, Bryan R. Lajoie, Amartya Sanyal, Zhiping Weng, Troy W. Whitfield, and Jie Wang are members of The ENCODE Project Consortium.
Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1371/journal.pbio.1001046