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dc.contributor.authorAlexandrov, Ilya M.
dc.contributor.authorIvshina, Maria
dc.contributor.authorJung, Dae Young
dc.contributor.authorFriedline, Randall H.
dc.contributor.authorKo, Hwi Jin
dc.contributor.authorXu, Mei
dc.contributor.authorO'Sullivan-Murphy, Bryan
dc.contributor.authorBortell, Rita
dc.contributor.authorHuang, Yen-Tsung
dc.contributor.authorUrano, Fumihiko
dc.contributor.authorKim, Jason K.
dc.contributor.authorRichter, Joel D.
dc.date2022-08-11T08:10:15.000
dc.date.accessioned2022-08-23T17:01:16Z
dc.date.available2022-08-23T17:01:16Z
dc.date.issued2012-01-12
dc.date.submitted2012-04-24
dc.identifier.citationAlexandrov IM, Ivshina M, Jung DY, Friedline R, Ko HJ, et al. (2012) Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance. PLoS Genet 8(1): e1002457. doi:10.1371/journal.pgen.1002457 <a href="http://dx.doi.org/10.1371/journal.pgen.1002457">Link to article on publisher's site</a>
dc.identifier.issn1553-7390 (Linking)
dc.identifier.doi10.1371/journal.pgen.1002457
dc.identifier.pmid22253608
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43972
dc.description.abstractThe cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that several encoded proteins are involved in insulin signaling. An investigation of Cpeb1 knockout mice revealed that the expression of two particular negative regulators of insulin action, PTEN and Stat3, were aberrantly increased. Insulin signaling to Akt was attenuated in livers of CPEB-deficient mice, suggesting that they might be defective in regulating glucose homeostasis. Indeed, when the Cpeb1 knockout mice were fed a high-fat diet, their livers became insulin-resistant. Analysis of HepG2 cells, a human liver cell line, depleted of CPEB demonstrated that this protein directly regulates the translation of PTEN and Stat3 mRNAs. Our results show that CPEB regulated translation is a key process involved in insulin signaling.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=22253608&dopt=Abstract">Link to Article in PubMed</a>
dc.rights<p>Copyright: © 2012 Alexandrov et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</p>
dc.subjectTranscription Factors
dc.subjectmRNA Cleavage and Polyadenylation Factors
dc.subjectPTEN Phosphohydrolase
dc.subjectSTAT3 Transcription Factor
dc.subjectInsulin Resistance
dc.subjectGenetics and Genomics
dc.titleCytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance
dc.typeJournal Article
dc.source.journaltitlePLoS genetics
dc.source.volume8
dc.source.issue1
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1183&amp;context=pgfe_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/pgfe_pp/183
dc.identifier.contextkey2792620
refterms.dateFOA2022-08-23T17:01:16Z
html.description.abstract<p>The cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that several encoded proteins are involved in insulin signaling. An investigation of Cpeb1 knockout mice revealed that the expression of two particular negative regulators of insulin action, PTEN and Stat3, were aberrantly increased. Insulin signaling to Akt was attenuated in livers of CPEB-deficient mice, suggesting that they might be defective in regulating glucose homeostasis. Indeed, when the Cpeb1 knockout mice were fed a high-fat diet, their livers became insulin-resistant. Analysis of HepG2 cells, a human liver cell line, depleted of CPEB demonstrated that this protein directly regulates the translation of PTEN and Stat3 mRNAs. Our results show that CPEB regulated translation is a key process involved in insulin signaling.</p>
dc.identifier.submissionpathpgfe_pp/183
dc.contributor.departmentResearch Computing, Information Services Department
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentProgram in Gene Function and Expression
dc.contributor.departmentSchool of Medicine
dc.source.pagese1002457
dc.contributor.studentBryan O'Sullivan-Murphy


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