Show simple item record

dc.contributor.authorJiao, Baowei
dc.contributor.authorMa, Hong
dc.contributor.authorShokhirev, Maxim N.
dc.contributor.authorDrung, Alexander
dc.contributor.authorYang, Qin
dc.contributor.authorShin, JongDae
dc.contributor.authorLu, Shaolei
dc.contributor.authorByron, Meg
dc.contributor.authorKalantry, Sundeep
dc.contributor.authorMercurio, Arthur M.
dc.contributor.authorLawrence, Jeanne B.
dc.contributor.authorHoffmann, Alexander
dc.contributor.authorBach, Ingolf
dc.date2022-08-11T08:10:15.000
dc.date.accessioned2022-08-23T17:01:17Z
dc.date.available2022-08-23T17:01:17Z
dc.date.issued2012-04-27
dc.date.submitted2012-05-04
dc.identifier.citationCell. 2012 Apr 27;149(3):630-41. doi:10.1016/j.cell.2012.02.056
dc.identifier.issn1097-4172
dc.identifier.doi10.1016/j.cell.2012.02.056
dc.identifier.pmid22541433
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43974
dc.description.abstractIn female mouse embryos, somatic cells undergo a random form of X chromosome inactivation (XCI), whereas extraembryonic trophoblast cells in the placenta undergo imprinted XCI, silencing exclusively the paternal X chromosome. Initiation of imprinted XCI requires a functional maternal allele of the X-linked gene Rnf12, which encodes the ubiquitin ligase Rnf12/RLIM. We find that knockout (KO) of Rnf12 in female mammary glands inhibits alveolar differentiation and milk production upon pregnancy, with alveolar cells that lack RLIM undergoing apoptosis as they begin to differentiate. Genetic analyses demonstrate that these functions are mediated primarily by the paternal Rnf12 allele due to nonrandom maternal XCI in mammary epithelial cells. These results identify paternal Rnf12/RLIM as a critical survival factor for milk-producing alveolar cells and, together with population models, reveal implications of transgenerational epigenetic inheritance.
dc.language.isoen_US
dc.publisherCell Press
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22541433&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.cell.2012.02.056
dc.subjectUbiquitin-Protein Ligases
dc.subjectMammary Glands, Animal
dc.subjectX Chromosome Inactivation
dc.subjectGenetics and Genomics
dc.titlePaternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells
dc.typeJournal Article
dc.source.journaltitleCell
dc.source.volume149
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/pgfe_pp/185
dc.identifier.contextkey2822721
html.description.abstract<p>In female mouse embryos, somatic cells undergo a random form of X chromosome inactivation (XCI), whereas extraembryonic trophoblast cells in the placenta undergo imprinted XCI, silencing exclusively the paternal X chromosome. Initiation of imprinted XCI requires a functional maternal allele of the X-linked gene Rnf12, which encodes the ubiquitin ligase Rnf12/RLIM. We find that knockout (KO) of Rnf12 in female mammary glands inhibits alveolar differentiation and milk production upon pregnancy, with alveolar cells that lack RLIM undergoing apoptosis as they begin to differentiate. Genetic analyses demonstrate that these functions are mediated primarily by the paternal Rnf12 allele due to nonrandom maternal XCI in mammary epithelial cells. These results identify paternal Rnf12/RLIM as a critical survival factor for milk-producing alveolar cells and, together with population models, reveal implications of transgenerational epigenetic inheritance.</p>
dc.identifier.submissionpathpgfe_pp/185
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentDepartment of Cell Biology
dc.contributor.departmentDepartment of Cancer Biology
dc.contributor.departmentProgram in Gene Function and Expression
dc.source.pages630-41


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record