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    Coordination of cell growth and division by the ubiquitin-proteasome system

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    Authors
    Benanti, Jennifer A.
    UMass Chan Affiliations
    Program in Molecular Medicine
    Program in Gene Function and Expression
    Document Type
    Journal Article
    Publication Date
    2012-04-19
    Keywords
    Ubiquitin-Protein Ligase Complexes
    Ubiquitin
    Cell Cycle
    Proteolysis
    Genetics and Genomics
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.semcdb.2012.04.005
    Abstract
    The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.
    Source
    Semin Cell Dev Biol. 2012 Apr 19. [Epub ahead of print] doi 10.1016/j.semcdb.2012.04.005
    DOI
    10.1016/j.semcdb.2012.04.005
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/43976
    PubMed ID
    22542766
    Related Resources
    Link to article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.semcdb.2012.04.005
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