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dc.contributor.authorBenanti, Jennifer A
dc.date2022-08-11T08:10:15.000
dc.date.accessioned2022-08-23T17:01:17Z
dc.date.available2022-08-23T17:01:17Z
dc.date.issued2012-04-19
dc.date.submitted2012-05-21
dc.identifier.citationSemin Cell Dev Biol. 2012 Apr 19. [Epub ahead of print] doi 10.1016/j.semcdb.2012.04.005
dc.identifier.issn1084-9521 (Linking)
dc.identifier.doi10.1016/j.semcdb.2012.04.005
dc.identifier.pmid22542766
dc.identifier.urihttp://hdl.handle.net/20.500.14038/43976
dc.description.abstractThe coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22542766&dopt=Abstract">Link to article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/j.semcdb.2012.04.005
dc.subjectUbiquitin-Protein Ligase Complexes
dc.subjectUbiquitin
dc.subjectCell Cycle
dc.subjectProteolysis
dc.subjectGenetics and Genomics
dc.titleCoordination of cell growth and division by the ubiquitin-proteasome system
dc.typeJournal Article
dc.source.journaltitleSeminars in cell and developmental biology
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/pgfe_pp/187
dc.identifier.contextkey2878937
html.description.abstract<p>The coupling of cellular growth and division is crucial for a cell to make an accurate copy of itself. Regulated protein degradation by the ubiquitin-proteasome system (UPS) plays an important role in the coordination of these two processes. Many ubiquitin ligases, in particular the Skp1-Cullin-F-box (SCF) family and the Anaphase-Promoting Complex (APC), couple growth and division by targeting cell cycle and metabolic regulators for degradation. However, many regulatory proteins are targeted by multiple ubiquitin ligases. As a result, we are only just beginning to understand the complexities of the proteolytic regulatory network that connects cell growth and the cell cycle.</p>
dc.identifier.submissionpathpgfe_pp/187
dc.contributor.departmentProgram in Molecular Medicine
dc.contributor.departmentProgram in Gene Function and Expression


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